The Carbohydrate and Caloric Content of Concomitant Medications

for Children with Epilepsy on the Ketogenic Diet

Denis Lebel, Caroline Morin, Micheline Laberge, Nathalie Achim and Lionel Carmant

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ABSTRACT: Background: The ketogenic diet for children with refractory epilepsy requires a strict control of the amount of ingested carbohydrates. This can be altered by medication prescribed for the epileptic syndrome or for intercurrent illnesses. The goal of this paper is to compile the carbohydrate and caloric content of commonly used medications in this population. Methods: We compiled a list of frequently used medications with the help of Canadian manufacturers and the Compendium of Pharmaceuticals and  Specialties. We also tested a worst case scenario calculation based on the weight of the tablet. Results: We list the carbohydrate and caloric content of 790 medications studied. Our worst case scenario gives an over-estimate in all cases, making adjustments based on this calculation in an emergency setting safe. Conclusion: We propose this list as a tool for physicians, dietitians, nurses and pharmacists. The list can easily be adjusted, based on local practices and reviewed periodically.

RÉSUMÉ: Le contenu en hydrates de carbone et en calories des médicaments concomitants chez les enfants épileptiques suivant la diète cétogène. Introduction: La diète cétogène chez les enfants dont l’épilepsie est résistante au traitement demande un contrôle strict de la quantité d’hydrates de carbone ingérée qui peut être influencée par la médication prescrite pour le syndrome épileptique ou pour une maladie intercurrente. Le but de cet article est de compiler le contenu en hydrates de carbone et en calories de médicaments d’usage courant dans cette population. Méthodes: Nous avons compilé une liste des médicaments d’usage courant avec l’aide de manufacturiers Canadiens et du Compendium des produits et spécialités pharmaceutiques. Nous avons également testé un calcul basé sur le poids du comprimé qui tenait compte de la pire situation possible. Résultats: Nous avons dressé une liste du contenu en hydrates de carbone et en calories de 790 médicaments. Notre calcul selon la pire situation surestime dans tous les cas, ce qui assure la sécurité de l’ajustement basé sur ce calcul en situation d’urgence. Conclusions: Nous proposons cette liste comme outil pour les médecins, les diététistes, les infirmières et les pharmaciens. La liste peut facilement être ajustée selon les pratiques locales et révisée périodiquement. Can. J. Neurol. Sci. 2001; 28: 322-340

The ketogenic diet is a form of treatment used in children, and sometimes adults, with refractory epilepsies or with significant adverse events secondary to the anticonvulsants.1,2 The first report on the diet came in 1911 and it was supported by a second report 10 years later3,4 but the diet became almost obsolete following the release of new medications in the 1940s. Due to the partial  efficacy of phenytoin, further efforts to improve the diet were later introduced leading to better compliance and again encouraging results.5 Once again, in the ’70s, the advent of new medications particularly valproic acid, lessened the interest in the diet.6 Over the past 10 years, because of its persistent efficacy in children with refractory and even more benign epilepsies, there has been increasing interest from families, clinicians and researchers to use the diet to a greater extent and to better understand it.6

Although its mechanisms of action are still not understood, THE CANADIAN JOURNALOF NEUROLOGICAL SCIENCES we now realize that complete or even partial loss of ketosis can impair seizure control.7 Strict compliance with the diet is, therefore, of foremost importance. Some animal models show an increased seizure threshold during treatment with the diet.8 We also know that ketone bodies are present in the blood and are able to cross the blood brain barrier, to serve as the principal source of energy to the brain. However, electrophysiological studies do not indicate that decreased neuronal excitability is mediated by a direct effect of ketone bodies.9 Ketosis is From the Department of Pharmacy (DL, CM, NA) and Pediatrics (ML, LC), Hôpital Ste-Justine, University of Montreal, Montreal, QC Canada RECEIVED DECEMBER 14, 2000. ACCEPTED INFINALFORMJUNE 20, 2001.

Reprint requests to: Lionel Carmant, Hôpital Ste-Justine, Department of Pediatrics, Division of Neurology, 3175 Côte Ste-Catherine, Montreal, QC, Canada

H3T1C5 established by the activation of fatty acid oxidation, secondary to the lack of carbohydrate reserves induced by the starvation period and maintained by the high lipid/carbohydrate + protein content of the diet. The constituents of the diet are calculated to provide a ratio of lipids/proteins + carbohydrates of 3/1 to 4/1. Carbohydrates can only make up 20% of total calorie intake in a diet already limited on calorie supply, compared to more than 50% in a normal diet.

The diet is usually maintained for a minimum period of two to six months and, if associated with a significant improvement, is pursued for at least two years. During this two-year period, infectious illnesses and other medical problems are common in a population of children with refractory epilepsy often with an associated mental handicap.

Although syrups are usually contra-indicated due to their high carbohydrate content in the form of sucrose, maltose, sorbitol, mannitol, alcohol or starch, the “sugar free” label of drug tablets does not guarantee that ketosis will not be affected. The “sugar free” label is used primarily for diabetics and these tablets may contain sorbitol, a carbohydrate  which will not affect glycemia but might affect ketosis in the diet. The carbohydrate content of tablets, including anticonvulsants and other concomitant drugs, can be difficult to manage for the physicians, nurses and pharmacists.

Published material from the US has been reviewed but cannot be used in Canada because the drug formulations are different in the US.10 The goal of this paper is to review the carbohydrate and calorie content of the drugs most commonly used by children to help clinicians evaluate their  antiketotic effects.

METHODS

Between November 1998 and November 1999 we listed all drugs used on the neurology and intensive care wards that are available in liquid form, especially anticonvulsants, antibiotics, analgesics, antipyretic drugs, anti-inflammatory medications, laxatives and vitamins.We also reviewed tablet and capsule forms of anticonvulsants, antibiotics, and laxatives.

Their monography was reviewed in the Compendium of Pharmaceuticals and Specialties (CPS) and each company was then contacted by mail to complete missing data about the drug’s content of carbohydrates and their derivatives, as well as their calorie content. We sent a total of 894 requests for information.

On 46 drugs we tested a worst case scenario formula to evaluate the maximal carbohydrate content of a tablet or capsule. We measured the weight of 10 tablets, subtracted the amount of active material in these tablets and then divided the result by the number of tablets weighed. We considered this number to represent the maximal carbohydrate content of the pharmaceutical formulation in grams and extrapolated the energy content by multiplying the calculated number by 4 kCalories.

RESULTS

Thanks to the collaboration of most of the pharmaceutical companies, we were able to compile the data published in Table 1. This is, we believe, a useful tool for pharmacists, nurses and physicians involved in the care of these children. The list of drugs can easily be increased based on local practices and reviewed after a few years.

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The results of the worst case scenario calculations showed that we never underestimated the content of a tablet or capsule ( Table 2). The tendency is actually to overestimate the carbohydrate content of the drugs. For example, a Biaxin tablet, with 250 mg of active ingredient weighs 0,520g. When we substract the active ingredient, we have 270 mg left. The worst case scenario assumes that all of this weight is made of carbohydrates. When we compare the results of the worst case scenario (1.08 kCal) to the data obtained from the manufacturer (0.210 kCal), we found that the worse case scenario overestimates the caloric content.

DISCUSSION

Carbohydrates and loss of ketosis. The ingestion of an excessive amount of carbohydrate in the diet stimulates the release of insulin, which stops the release of free fatty acids from the fat deposits, thus depriving the liver of its substrate for the production of  ketones.11,12 This could occur when a new medication is prescribed to a child on the ketogenic diet or when drugs are given to this child for an acute illness.

The control of the insulin release by glucose is important for patients on the ketogenic diet. Both a high basal serum glucose level and an elevated peak level can increase the magnitude of subsequent insulin release for several hours.12 This is a possible explanation for the prolonged loss of ketosis seen when patients on the ketogenic diet ingest an excessive amount of carbohydrates.

When this occurs, returning to ketosis may take 24 hours or more, since the insulin response to subsequent carbohydrate or amino acid exposure with the next meals may be greater. This “break” in ketosis often offsets seizure control. A short period (12 to 24 hours) of fasting may be necessary for a quick return to the ketotic state, but seizure control might not be regained.5 Clinicians should select, whenever it is possible, medications that will not affect the ketogenic diet. If a drug with a significant number of calories provided by   carbohydrates must be selected, the diet should be adjusted accordingly.

The data that has been published to help the clinician make these decisions are either out of date or compiled in the United States.9 Canadian clinicians now have a tool to help them select a formulation that is less likely to affect the diet. If this list fails to provide information needed by the clinician, the worst case scenario can be used to evaluate the caloric content of a drug. As it always overestimates the caloric content of a drug, we feel the table is safe to use.

Drug-diet interactions

One must also be aware of unfavorable interactions between drugs and the diet. Initially, because of its broad spectrum of efficacy and also because it is a branched chain fatty acid,valproic acid was believed to be able to replace the diet with a lesser requirement of family training and teaching.6 This has not been the case. In fact, a number of significant interactions exist between valproic acid and the diet. One of its metabolites, 2- propylpentanoyl-CoA-(valproyl-CoA) has been implicated in the inhibition of mitochondrial fatty acid oxidation.12 Valproic acid may also interfere with beta-oxidation of medium-chain fatty acids.13 This may be due to a direct action of 2-n-propyl-4pentenoic acid.13 Clinically, we have not found valproic acid to Volume 28, No. 4 – November 2001 THE CANADIAN JOURNAL OF NEUROLOGICALSCIENCES significantly interfere with ketogenesis in children on the diet but valproic acid may increase the risk of side effects in patients on the ketogenic diet.14

In younger children, we recommend the use of the capsule form of divalproex, available in the US under the brand name of Depakote, because it contains far less carbohydrates than the liquid formulation.15 Phenobarbital should be used with caution because serum concentration can increase as much as 100% over the baseline when the diet is started.16 Phenobarbital elimination is slowed down in acidotic state. Other anticonvulsant drugs that can directly affect ketosis include drugs that can reduce insulin release, such as phenytoin,1 7 and acetazolamide with high glucose concentrations.1 8 Other anticonvulsant drugs can increase insulin release like phenobarbital19 and acetazolamide with low glucose concentrations.18

Finally, one needs to be careful when using beta-blocking agents. Beta-blocking agents inhibit fatty acid and gluconeogenetic substrate release and reduce plasma glucagon levels.20 Patients on both beta-blocking agents and a diet low in carbohydrates and protein, or those undergoing fasting, are potentially more susceptible to hypoglycemia with decreased capability of ketogenesis. Beta-blocking agents may also decrease the symptoms of hypoglycemia. We therefore avoid such treatment when possible, especially during early stages of treatment.

In conclusion, we believe the information compiled in the tables represents a useful tool for the professionals involved in ketogenic diet programs. We also want to reinforce the need to be aware of the many possible interactions between drugs (anticonvulsants and others) and the mechanisms involved in the maintenance of ketosis.

REFERENCES

1. Freeman JM, Vining EP, Pillas DJ, et al. The efficacy of the ketogenic diet-1998: a prospective evaluation of intervention in 150 children. Pediatrics 1998;102:1358-1363.

2. Barboka CJ. Epilepsy in adults: results of treatment by ketogenic diet in one hundred cases. Arch Neurol Psychiatr  1930;23:904-914.

3. Guelpa G, Marie A. La lutte contre l’épilepsie par la désintoxication et par la rééducation alimentaire. Revue de Thérapie Medico- Chirurgicale 1911;78:8-13.

4. Wilder RM. The effect of ketonemia on the course of epilepsy. Mayo Clin Bull 1921;2:(307);314.

5.Livingston SL. Comprehensive Management of Epilepsy in Infants, Childhood and Adolescence. Springfield, IL: Charles C Thomas. 1972:378-405.

6.Wheless JW. The ketogenic diet: fact or fiction. J Child Neurol 1995;10:419-423.

7.Huttenlocher PR. Ketonemia and seizures: metabolic and anticonvulsant effects of two ketogenic diets in childhood epilepsy.Pediatr Res 1976;10(5):536-540.

8.Bough KJ, Matthews PJ, Eagles DA. A ketogenic diet has different effects upon seizures induced by maximal electroshock and by pentylenetetrazole infusion. Epilepsy Res 2000;38:105-114.

9.Thio LL, Wong M, Yamada KA. Ketone bodies do not directly alter excitatory or inhibitory hippocampal synaptic transmission. Neurology 2000;54:325-331.

10. Feldstein TJ. Carbohydrate and alcohol content of 200 oral liquid medications for use in patients receiving ketogenic diets. Pediatrics 1996;97:506-511.

11. Tallian KB, Nahata MC, Tsao CY. Role of the ketogenic diet with intractable seizures. Ann Pharmacother 1998;32:349-361.

12. McGarry JD. Glucose-fatty acid interactions in health and disease. Am J Clin Nutr 1998;67(Suppl):500S-504S.

13. Li J, Norwood DL, Mao LF, Schulz H. Mitochondrial metabolism of valproic acid. Biochemistry 1991;30:388-394.

14. Bjorge SM, Baillie TA. Inhibition of medium-chain fatty acid beta-oxidation in vitro by valproic acid and its unsaturated metabolite, 2-n-propyl-4-pentenoic acid. Biochem Biophys Res Commun 1985;132:245-252.

15. Ballaban-Gil K, Callahan C, O’Dell C, et al. Complications of the ketogenic diet. Epilepsia 1998;39:744-748.

16. Kinsman SL, Vining EPG, Quakey SA, Mellitis D, Freeman JM. Efficacy of the ketogenic diet for intractable seizure disorders: review of 58 cases. Epilepsia 1992;33:1132-1136.

17. Kizer JS, Vargas-Gordon M, Brendel K, Bressler R. The in vitro inhibition of insulin secretion by diphenylhydantoin. J Clin Invest 1970;49:1942-1948.

18. Boquist L, Backman AM, Stromberg C. Hyperglycemia produced in mice by administration of acetazolamide and diphenylhydantoin. Eur J Pharmacol 1980;64:325-332.

19. Venkatesan N, Davidson MB, Simsolo RB, Kern PA. Phenobarbital treatment enhances insulin-mediated glucose metabolism and improves lipid metabolism in the diabetic rat. Metabolism 1994;43:348-356.

20. Karam JH. Reversible insulin resistance in noninsulin-dependent diabetes mellitus. Horm Metab Res 1996;28:440-444. LE JOURNAL CANADIEN DES SCIENCES NEUROLOGIQUES

Table 1: Caloric content of drugs, listed by generic names

Drug, concentration and presentation Commercial name and company Caloric content* Caloric content*

– CH§ (Kcal) – Total (Kcal)

5-aminosalicylic acid, 250 mg / Tablet Pentasa (Hoechst Marion Roussel) 0,00 Nd

5-aminosalicylic acid, 500 mg / Tablet Pentasa (Hoechst Marion Roussel) 0,00 Nd

Acebutolol HCl, 100 mg / Tablet Novo-Acebutol (Novopharm) 0,360 0,375

Acebutolol HCl, 200 mg / Tablet Novo-Acebutol (Novopharm) 0,720 0,749

Acebutolol HCl, 400 mg / Tablet Novo-Acebutol (Novopharm) 0,025 0,066

Acetaminophen, 16 mg/ml / Liquid Tempra (Mead Johnson) Nd 1,78

Acetaminophen, 16 mg/ml / Liquid Atasol (Carter Horner) 1,44 2,40

Acetaminophen, 16 mg/ml / Liquid Pms-acetaminophen (Pharmascience) 1,7 Nd

Acetaminophen, 160 mg / Chewable tablet Tylenol (McNeil) Nd 2,5

Acetaminophen, 160 mg / Chewable tablet Tylenol sans sucrose (McNeil) Nd 2,0

Acetaminophen, 32 mg/ml / Liquid Tempra (Mead Johnson) Nd 1,78

Acetaminophen, 32 mg/ml / Liquid Tylenol elixir (McNeil) Nd 1,76

Acetaminophen, 32 mg/ml / Liquid Tylenol suspension liquid (grape) (McNeil) Nd 2,22

Acetaminophen, 32 mg/ml / Liquid Tylenol suspension liquid (bubblegum) (McNeil) Nd 2,40

Acetaminophen, 32 mg/ml / Liquid Pms-acetaminophen (Pharmascience) 1,7 Nd

Acetaminophen, 325 mg / Tablet Tylenol (McNeil) Nd 0,2

Acetaminophen, 325 mg / Tablet Novo-Gesic (Novopharm) 0,039 Nd

Acetaminophen, 500 mg / Tablet Tylenol (McNeil) Nd 0,3

Acetaminophen, 500 mg / Tablet Novo-Gesic (Novopharm) 0,062 Nd

Acetaminophen, 80 mg / Chewable tablet Tylenol (McNeil) Nd 1,2

Acetaminophen, 80 mg / Chewable tablet Tylenol sans sucrose (McNeil) Nd 1

Acetaminophen, 80 mg/ml / Liquid Tempra (Mead Johnson) Nd 1,40

Acetaminophen, 80 mg/ml / Liquid Tylenol drops (McNeil) Nd 0,98

Acetaminophen, 80 mg/ml / Liquid Tylenol suspension liquid (McNeil) Nd 2,10

Acetaminophen, 80 mg/ml / Liquid Pms-acetaminophen (Pharmascience) 0,36 Nd

Acetaminophen, 80 mg/ml / Liquid Atasol drops (Carter Horner) 1,79 2,40

Acetaminophen-caffeine-codeine phosphate

(C15), 300 mg-15 mg-15 mg / Tablet Novo-Gesic C15 (Novopharm) 0,148 0,188

Acetaminophen-caffeine-codeine phosphate

(C30), 300 mg-15 mg-30 mg / Tablet Novo-Gesic C30 (Novopharm) 0,154 0,195

Acetaminophen-caffeine-codeine phosphate

(C8), 300 mg-15 mg-8 mg / Tablet Novo-Gesic C8 (Novopharm) 0,145 0,184

Acetazolamide, 250 mg / Tablet Apo-Acetazolamide (Apotex) Nd 0,79

Acetazolamide, 250 mg / Tablet Diamox (Berlex) Nd 1,0

Acetazolamide, 250 mg / Tablet Novo-Zolamide (Novopharm) 0,100 0,143

Acetylsalicylic acid, 325 mg / Tablet Novasen Novasen SP.C. (Novopharm) 0,239 Nd

Acetylsalicylic acid, 650 mg / Tablet Novasen Novasen SP.C. (Novopharm) 0,479 Nd

Acyclovir, 40 mg/ml / Liquid Zovirax (Glaxo Wellcome) 1,26 2,62

Alfacalcidol, 0,2 mcg/ml / Liquid One-Alpha (Leo Pharma) 2,63 Nd

Alfacalcidol, 0,25 mcg / Capsule One-Alpha (Leo Pharma) 1,15 Nd

Alfacalcidol, 1 mcg / Capsule One-Alpha (Leo Pharma) 1,15 Nd

Allopurinol, 100 mg / Tablet Novo-Purol (Novopharm) 0,458 0,484

Allopurinol, 200 mg / Tablet Novo-Purol (Novopharm) 0,057 0,084

Allopurinol, 300 mg / Tablet Novo-Purol (Novopharm) 0,346 0,395

Alprazolam, 0,25 mg / Tablet Novo-Alprazol (Novopharm) 0,416 0,450

Alprazolam, 0,50 mg / Tablet Novo-Alprazol (Novopharm) 0,413 0,482

Aluminium + magnesium hydroxyde, 45 mg + 40 mg / Liquid Maalox (Novartis Pharma) Nd 0,04

Aluminium + magnesium hydroxyde, / Liquid Almagel (Atlas laboratories) 0,20 Nd

Aluminium hydroxyde, 64 mg/ml / Liquid Amphogel (Axcan Pharma) Nd 0,60

Amantadin, 10 mg/ml / Liquid Symmetrel (Du Pont Pharma) 2,58 Nd

Amiloride HCl/Hydrochlorothiazide, 5/50 mg / Tablet Novamilor (Novopharm) 0,401 0,412

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Drug, concentration and presentation Commercial name and company Caloric content* Caloric content*

– CH§ (Kcal) – Total (Kcal)

Aminocaproic acid, 250 mg/ml / Liquid Amicar (Wyeth-Ayerst) Nd 2,40

Amitriptylin, 10 mg / Tablet Novo-Triptyn (Novopharm) 0,039 0,065

Amitriptylin, 25 mg / Tablet Novo-Triptyn (Novopharm) 0,046 0,063

Amitriptylin, 2 mg/ml / Liquid Elavil (Merck Sharp & Dohme) 2,63 Nd

Amitriptylin, 50 mg / Tablet Novo-Triptyn (Novopharm) 0,082 0,138

Amoxicillin + clavulanic acid, 50 + 12,5 mg/ml / Liquid Clavulin (Smithkline Beecham Pharma) 0,18 Nd

Amoxicillin + potassium clavulanate, 25+6,25 mg/ml / Liquid Clavulin (SmithKline Beecham Pharma) 0,18 Nd

Amoxicillin + potassium clavulanate, 250 mg + 125 mg / Tablet Clavulin (SmithKline Beecham Pharma) 1,20 Nd

Amoxicillin + clavulanate de potassium, 500 mg + 125 mg / Tab Clavulin (SmithKline Beecham Pharma) 1,80 Nd

Amoxicillin, 125 mg / Chewable tablet Amoxil (Wyeth-Ayerst) Nd 0,50

Amoxicillin, 25 mg/ml / Liquid Amoxil (Wyeth-Ayerst) Nd 0,40

Amoxicillin, 25 mg/ml / Liquid Apo-Amoxi hypoglucidic (Apotex) Nd 0,026

Amoxicillin, 25 mg/ml / Liquid Novamoxin hypoglucidic (Novopharm) 0,48 Nd

Amoxicillin, 25 mg/ml / Liquid Nu-amoxi (Nu-Pharm) 1,78 Nd

Amoxicillin, 25 mg/ml / Liquid Apo-amoxi (Apotex) 1,79 Nd

Amoxicillin, 25 mg/ml / Liquid Novamoxin (Novopharm) 2,27 Nd

Amoxicillin, 250 mg / Capsule Amoxil (Wyeth-Ayerst) Nd 0,20

Amoxicillin, 250 mg / Capsule Apo-Amoxi (Apotex) Nd 0,21

Amoxicillin, 250 mg / Capsule Nu-Amoxi (Nu-Pharm) Nd 0,21

Amoxicillin, 250 mg / Capsule Novamoxin (Novopharm) 0,082 0,126

Amoxicillin, 250 mg / Chewable tablet Amoxil (Wyeth-Ayerst) Nd 1,0

Amoxicillin, 50 mg/ml / Liquid Amoxil (Wyeth-Ayerst) Nd 0,32

Amoxicillin, 50 mg/ml / Liquid Apo-Amoxi hypoglucidic (Apotex) Nd 0,026

Amoxicillin, 50 mg/ml / Liquid Novamoxin hypoglucidic (Novopharm) 0,41 Nd

Amoxicillin, 50 mg/ml / Liquid Apo-amoxi (Apotex) 1,78 Nd

Amoxicillin, 50 mg/ml / Liquid Nu-amoxi (Nu-Pharm) 1,78 Nd

Amoxicillin, 50 mg/ml / Liquid Novamoxin (Novopharm) 2,14 Nd

Amoxicillin, 500 mg / Capsule Amoxil (Wyeth-Ayerst) Nd 0,40

Amoxicillin, 500 mg / Capsule Apo-Amoxi (Apotex) Nd 0,36

Amoxicillin, 500 mg / Capsule Nu-Amoxi (Nu-Pharm) Nd 0,36

Amoxicillin, 500 mg / Capsule Novamoxin (Novopharm) 0,164 0,245

Ampicillin, 100 mg/ml / Liquid Novo-Ampicillin (Novopharm) 1,87 1,87

Ampicillin, 25 mg/ml / Liquid Apo-ampi (Apotex) Nd 1,82

Ampicillin, 25 mg/ml / Liquid Nu-ampi (Nu-Pharm) Nd 1,82

Ampicillin, 25 mg/ml / Liquid Novo-Ampicillin (Novopharm) 2,27 2,27

Ampicillin, 250 mg / Capsule Apo-Ampi (Apotex) Nd 0,22

Ampicillin, 250 mg / Capsule Nu-Ampi (Nu-Pharm) Nd 0,22

Ampicillin, 250 mg / Capsule Novo-Ampicillin (Novopharm) 0,104 0,148

Ampicillin, 50 mg/ml / Liquid Apo-ampi (Apotex) Nd 1,70

Ampicillin, 50 mg/ml / Liquid Nu-ampi (Nu-Pharm) Nd 1,70

Ampicillin, 50 mg/ml / Liquid Novo-Ampicillin (Novopharm) 2,16 2,16

Ampicillin, 500 mg / Capsule Apo-Ampi (Apotex) Nd 0,39

Ampicillin, 500 mg / Capsule Nu-Ampi (Nu-Pharm) Nd 0,39

Ampicillin, 500 mg / Capsule Novo-Ampicillin (Novopharm) 0,078 0,155

ASA-Caffeine-Codeine phosphate, 1 tablet / Tablet Novo A.C. & C. (Novopharm) 0,067 0,067

Atenolol, 100 mg / Tablet Novo-Atenol (Novopharm) 0,188 0,222

Atenolol, 50 mg / Tablet Novo-Atenol (Novopharm) 0,094 0,111

Azithromycin, 1000 mg / Powder Zithromax (Pfizer) 38,828 Nd

Azithromycin, 20 mg/ml / Liquid Zithromax (Pfizer) 3,15 Nd

Azithromycin, 250 mg / Capsule Zithromax (Pfizer) 0,928 Nd

Azithromycin, 40 mg/ml / Liquid Zithromax (Pfizer) 3,16 Nd

Azithromycin, 600 mg / Tablet Zithromax (Pfizer) 0,348 Nd

Bacampicillin, chlorhydrate, 400 mg / Tablet Penglobe (Astra Pharma) Nd 0,10

Bacampicillin, chlorhydrate, 800 mg / Tablet Penglobe (Astra Pharma) Nd 0,20

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Drug, concentration and presentation Commercial name and company Caloric content* Caloric content*

– CH§ (Kcal) – Total (Kcal)

Baclofen, 20 mg / Tablet Novo-Baclofen (Novopharm) 0,132 0,156

Benzydamine, 0,15 % / Liquid Novo-Benzydamine (Novopharm) 0,808 Nd

Bisacodyl, 5 mg / Dragee Dulcolax (Boehringer Ingelheim) Nd 0,26

Bisacodyl, 5 mg / Tablet Apo-Bisacodyl (Apotex) Nd 0,48

Bisacodyl, 5 mg / Tablet Soflax EX (Pharmascience) 0,12 Nd

Bismuth subsalicylate, 17,6 mg/ml / Liquid Pepto-bismol (Procter & Gamble) 1,00 Nd

Bromazepam, 3 mg / Tablet Novo-Bromazepam (Novopharm) 0,400 0,417

Bumetanide, 1 mg / Tablet Burinex (Leo Pharma) 0,61 Nd

Bumetanide, 2 mg / Tablet Burinex (Leo Pharma) 0,74 Nd

Bumetanide, 5 mg / Tablet Burinex (Leo Pharma) 1,17 Nd

Buspirone, 10 mg / Tablet Novo-Buspirone (Novopharm) 0,487 0,499

Calcitriol, 1 mcg/ml / Liquid Rocaltrol (Hoffman-La Roche) 8,60 Nd

Calcium gluconate + glucoheptonate, 20 mg/ml / Liquid Calcium Stanley (Stanley Pharmaceuticals) Nd 0,04

Calcium lactobionate, / Liquid Calcium-Sandoz (Sandoz) Nd 1,35

Calcium, 500 mg Ca elem. / Capsule Calsan (Novartis Sante Familiale) Nd 5,85

Captopril, 100 mg / Tablet Novo-Captopril (Novopharm) 0,311 0,329

Captopril, 12,5 mg / Tablet Novo-Captopril (Novopharm) 0,039 0,041

Captopril, 25 mg / Tablet Novo-Captopril (Novopharm) 0,078 0,082

Captopril, 50 mg / Tablet Novo-Captopril (Novopharm) 0,156 0,165

Carbamazepine, 100 mg / Chewable tablet Tegretol (Novartis Pharma) Nd 1,08

Carbamazepine, 20 mg/ml / Liquid Tegretol (Novartis Pharma) Nd 1,79

Carbamazepine, 200 mg / Tablet Apo-Carbamazepine (Apotex) Nd 0,35

Carbamazepine, 200 mg / Tablet Nu-Carbamazepine (Nu-Pharm) Nd 0,35

Carbamazepine, 200 mg / Controled release tablet Tegretol CR (Novartis Pharma) Nd 0

Carbamazepine, 200 mg / Tablet Tegretol (Novartis Pharma) 0,00 Nd

Carbamazepine, 200 mg / Tablet Novo-Carbamaz (Novopharm) 0,031 0,048

Carbamazepine, 200 mg / Controled release tablet Tegretol (Novartis Pharma) Nd 2,12

Carbamazepine, 400 mg / Controled release tablet Tegretol CR (Novartis Pharma) Nd 0

Carnitine, 100 mg/ml / Liquid Carnitor (Sigma-Tau Pharmaceuticals) 0,20 Nd

Cefaclor, 25 mg/ml / Liquid Ceclor (Eli Lilly) Nd 2,52

Cefaclor, 250 mg / Capsule Pms-Cefaclor (Pharmascience) 0,14 Nd

Cefaclor, 250 mg / Capsule Apo-Cefaclor (Apotex) 0,28 Nd

Cefaclor, 50 mg/ml / Liquid Ceclor (Eli Lilly) Nd 2,42

Cefaclor, 500 mg / Capsule Pms-Cefaclor (Pharmascience) 0,28 Nd

Cefaclor, 500 mg / Capsule Apo-Cefaclor (Apotex) 0,317 Nd

Cefaclor, 75 mg/ml / Liquid Ceclor (Eli Lilly) Nd 2,24

Cefixime, 20 mg/ml / Liquid Suprax (Rhône-Poulenc Rorer) 2,22 Nd

Cefixime, 400 mg / Tablet Suprax (Rhône-Poulenc Rorer) 0,396 Nd

Cefprozil, 25 mg/ml / Liquid Cefzil (Bristol-Myers Squibb) Nd 1,50

Cefprozil, 250 mg / Tablet Cefzil (Bristol-Myers Squibb) 0,064 Nd

Cefprozil, 50 mg/ml / Liquid Cefzil (Bristol-Myers Squibb) Nd 1,30

Cefprozil, 500 mg / Tablet Cefzil (Bristol-Myers Squibb) 0,128 Nd

Cefuroxime axetil, 25 mg/ml / Liquid Ceftin (Glaxo Wellcome) 2,45 2,59

Cefuroxime axetil, 250 mg / Tablet Ceftin (Glaxo Wellcome) 0,00 Nd

Cefuroxime axetil, 500 mg / Tablet Ceftin (Glaxo Wellcome) 0,00 Nd

Cephalexin, 25 mg/ml / Liquid Keflex (Eli Lilly) Nd 2,48

Cephalexin, 25 mg/ml / Liquid Novo-Lexin (Novopharm) 2,32 2,32

Cephalexin, 25 mg/ml / Liquid Pms-cephalexin (Pharmascience) 2,48 Nd

Cephalexin, 250 mg / Capsule Novo-Lexin (Novopharm) 0,044 0,109

Cephalexin, 250 mg / Tablet Apo-Cephalex (Apotex) Nd 0,51

Cephalexin, 250 mg / Tablet Nu-Cephalex (Nu-Pharm) Nd 0,51

Cephalexin, 250 mg / Tablet Novo-Lexin (Novopharm) 0,075 0,104

Cephalexin, 250 mg / Tablet Pms-cephalexin (Pharmascience) 0,51 Nd

Cephalexin, 50 mg/ml / Liquid Keflex (Eli Lilly) Nd 2,42

Volume 28, No. 4 – November 2001 327

THE CANADIAN JOURNALOF NEUROLOGICAL SCIENCES

Drug, concentration and presentation Commercial name and company Caloric content* Caloric content*

– CH§ (Kcal) – Total (Kcal)

Cephalexin, 50 mg/ml / Liquid Novo-Lexin (Novopharm) 2,23 2,23

Cephalexin, 50 mg/ml / Liquid Pms-cephalexin (Pharmascience) 2,42 Nd

Cephalexin, 500 mg / Capsule Novo-Lexin (Novopharm) 0,088 0,211

Cephalexin, 500 mg / Tablet Apo-Cephalex (Apotex) Nd 1,02

Cephalexin, 500 mg / Tablet Nu-Cephalex (Nu-Pharm) Nd 1,02

Cephalexin, 500 mg / Tablet Novo-Lexin (Novopharm) 0,150 0,213

Cephalexin, 500 mg / Tablet Pms-cephalexin (Pharmascience) 1,02 Nd

Chloral hydrate, 100 mg/ml / Liquid Pms-chloralhydrate (Pharmascience) 2,0 Nd

Chloral hydrate, 500 mg / Capsule Novo-Chlorhydrate (Novopharm) 0,00 0,060

Chloramphenicol, 250 mg / Capsule Novo-Chlorocap (Novopharm) 0,863 0,932

Chlordiazepoxide, 10 mg / Capsule Novo-Poxide SP.C. (Novopharm) 0,465 0,476

Chlordiazepoxide, 25 mg / Capsule Novo-Poxide (Novopharm) 0,416 0,426

Chlordiazepoxide, 5 mg / Capsule Novo-Poxide (Novopharm) 0,482 0,492

Chloroquine, 250 mg / Tablet Novo-Chloroquine (Novopharm) 0,824 0,988

Chlorpheniramine, 4 mg / Tablet Novo-pheniram (Novopharm) 0,032 0,051

Chlorpromazine, 20 mg/ml / Liquid Largactil (Rhône-Poulenc Rorer) 2,86 Nd

Chlorpromazine, 5 mg/ml / Liquid Largactil (Rhône-Poulenc Rorer) 3,04 Nd

Chlorpromazine, 10 mg / Tablet Novo-Chlorpromazine (Novopharm) 0,064 0,094

Chlorpromazine, 100 mg / Tablet Novo-Chlorpromazine (Novopharm) 0,216 0,243

Chlorpromazine, 20 mg/ml / Liquid Chlorpromanyl (Technilab) Nd 3,40

Chlorpromazine, 200 mg / Tablet Novo-Chlorpromazine (Novopharm) 0,479 0,568

Chlorpromazine, 25 mg / Tablet Novo-Chlorpromazine (Novopharm) 0,124 0,139

Chlorpromazine, 40 mg/ml / Liquid Chlorpromanyl (Technilab) Nd 3,60

Chlorpromazine, 40 mg/ml / Liquid Largactil (Rhône-Poulenc Rorer) 0,78 Nd

Chlorpromazine, 50 mg / Tablet Novo-Chlorpromazine (Novopharm) 0,114 0,132

Chlorpropamide, 250 mg / Tablet Novo-Propamide (Novopharm) 0,933 0,978

Chlorthalidone, 100 mg / Tablet Novo-Thalidone (Novopharm) 0,037 0,049

Chlorthalidone, 50 mg / Tablet Novo-Thalidone (Novopharm) 0,037 0,049

Cholestyramine, 4 g/dose / Powder Novo-Cholamine Light (Novopharm) 0,00 0,00

Cholestyramine, 4 g/dose / Powder Novo-Cholamine (Novopharm) 16,09 16,09

Cimetidine, 200 mg / Tablet Novo-Cimetidine (Novopharm) 0,053 0,075

Cimetidine, 300 mg / Tablet Novo-Cimetidine (Novopharm) 0,059 0,093

Cimetidine, 400 mg / Tablet Novo-Cimetidine (Novopharm) 0,106 0,150

Cimetidine, 600 mg / Tablet Novo-Cimetidine (Novopharm) 0,159 0,226

Cimetidine, 800 mg / Tablet Novo-Cimetidine (Novopharm) 0,211 0,301

Ciprofloxacin, 250 mg / Tablet Cipro (Bayer) 0,171 Nd

Ciprofloxacin, 500 mg / Tablet Cipro (Bayer) 0,333 Nd

Ciprofloxacin, chlorhydrate, 100 mg/ml / Liquid Cipro (Bayer) 6,40 Nd

Cisapride, 1 mg/ml / Liquid Prepulsid (Jansen-Ortho) 0,80 Nd

Clarithromycin, 250 mg / Tablet Biaxin (Abbott Laboratories) 0,21 Nd

Clarithromycin, 25 mg/ml / Liquid Biaxin pediatric (Abbott Laboratories) 2,35 Nd

Clarithromycin, 500 mg / Tablet Biaxin (Abbott Laboratories) 0,00 Nd

Clindamycin, palmitate, 15 mg/ml / Liquid Dalacin C (Pharmacia & Upjohn) Nd 1,20

Clobazam, 10 mg / Tablet Frisium (Hoechst Marion Roussel) 0,398 Nd

Clomipramine HCl, 10 mg / Tablet Novo-Clopamine (Novopharm) 0,209 0,212

Clomipramine HCl, 25 mg / Tablet Novo-Clopamine (Novopharm) 0,00 0,003

Clomipramine HCl, 50 mg / Tablet Novo-Clopamine (Novopharm) 0,00 0,009

Clonazepam, 0,25 mg / Tablet Pms-Clonazepam (Pharmascience) 0,26 Nd

Clonazepam, 0,5 mg / Tablet Rivotril (Hoffman-La Roche) Nd 0,6

Clonazepam, 0,5 mg / Tablet Pms-Clonazepam (Pharmascience) 0,13 Nd

Clonazepam, 0,5 mg / Tablet Apo-Clonazepam (Apotex) 0,48 Nd

Clonazepam, 0,5 mg / Tablet Clonapam (ICN) 0,72 Nd

Clonazepam, 0,5 mg / Tablet Rho-Clonazepam (Rhodiapharm) 0,72 Nd

Clonazepam, 1 mg / Tablet Pms-Clonazepam (Pharmascience) 0,26 Nd

LE JOURNAL CANADIEN DES SCIENCES NEUROLOGIQUES

Drug, concentration and presentation Commercial name and company Caloric content* Caloric content*

– CH§ (Kcal) – Total (Kcal)

Clonazepam, 1,0 mg / Tablet Clonapam (ICN) 0,725 Nd

Clonazepam, 1,0 mg / Tablet Rho-Clonazepam (Rhodiapharm) 0,725 Nd

Clonazepam, 2 mg / Tablet Rivotril (Hoffman-La Roche) Nd 0,6

Clonazepam, 2 mg / Tablet Pms-Clonazepam (Pharmascience) 0,54 Nd

Clonazepam, 2 mg / Tablet Rho-Clonazepam (Rhodiapharm) 0.722 Nd

Clonazepam, 2,0 mg / Tablet Apo-Clonazepam (Apotex) 0,4 Nd

Clonazepam, 2,0 mg / Tablet Clonapam (ICN) 0,722 Nd

Clonidin, 0,1 mg / Tablet Novo-Clonidine (Novopharm) 0,418 0,431

Clonidin, 0,2 mg / Tablet Novo-Clonidine (Novopharm) 0,796 0,822

Clorazepate, 15 mg / Capsule Novo-Clopate (Novopharm) 0,601 0,632

Clorazepate, 3,75 mg / Capsule Novo-Clopate (Novopharm) 0,475 0,499

Clorazepate, 7,5 mg / Capsule Novo-Clopate (Novopharm) 0,463 0,487

Cloxacillin sodium, 250 mg / Capsule Apo-Cloxi (Apotex) Nd 0,20

Cloxacillin sodium, 250 mg / Capsule Nu-Cloxi (Nu-Pharm) Nd 0,21

Cloxacillin sodium, 500 mg / Capsule Apo-Cloxi (Apotex) Nd 0,33

Cloxacillin sodium, 500 mg / Capsule Nu-Cloxi (Nu-Pharm) Nd 0,33

Cloxacillin, 25 mg/ml / Liquid Apo-Cloxi (Apotex) Nd 1,79

Cloxacillin, 25 mg/ml / Liquid Nu-Cloxi (Nu-Pharm) Nd 1,79

Cloxacillin, 25 mg/ml / Liquid Orbenine (Wyeth-Ayerst) Nd 2,00

Cloxacillin, 25 mg/ml / Liquid Novo-Cloxin (Novopharm) 1,80 1,80

Cloxacillin, 250 mg / Capsule Orbenine (Wyeth-Ayerst) Nd 0,44

Cloxacillin, 250 mg / Capsule Novo-Cloxin (Novopharm) 0,139 0,210

Cloxacillin, 500 mg / Capsule Orbenine (Wyeth-Ayerst) Nd 0,30

Cloxacillin, 500 mg / Capsule Novo-Cloxin (Novopharm) 0,00 0,123

Codeine, 5 mg/ml / Liquid Codeine phosphate (Rougier) Nd 3,33

Cyclobenzaprine HCl, 10 mg / Tablet Novo-Cycloprine (Novopharm) 0,533 0,542

Cyclosporine, 100 mg/ml / Liquid Neoral (Sandoz) 7,00 Nd

Cyproheptadine, 0,4 mg/ml / Liquid Periactin (Johnson & Johnson Merck) 1,80 Nd

Dapsone, 100 mg / Tablet Avlosulfon (Wyeth-Ayerst) Nd 0,12

Demeclocycline, chlorhydrate, 150 mg / Tablet Declomycin (Wyeth-Ayerst) Nd 1,0

Demeclocycline, chlorhydrate, 300 mg / Tablet Declomycin (Wyeth-Ayerst) Nd 1,0

Desipramine HCl, 10 mg / Tablet Novo-Desipramine (Novopharm) 0,003 0,005

Desipramine HCl, 25 mg / Tablet Novo-Desipramine (Novopharm) 0,007 0,012

Desipramine HCl, 50 mg / Tablet Novo-Desipramine (Novopharm) 0,010 0,019

Desipramine HCl, 75 mg / Tablet Novo-Desipramine (Novopharm) 0,010 0,018

Desogestrel-ethinyl estradiol, 0,5 mg / Tablet Marvelon (Organon.) 0,281 Nd

Desogestrel-ethinyl estradiol, 1 mg / Capsule Marvelon (Organon.) 0,281 Nd

Desogestrel-ethinyl estradiol, 2 mg / Capsule Marvelon (Organon.) 0,281 Nd

Dexamethasone, 1 mg/ml / Liquid Pms-dexamethasone (Pharmascience) 0,64 Nd

Dexamethasone, 4 mg / Tablet Dexasone (ICN) 0,591 Nd

Dexamethasone, 500 mg / Tablet Dexasone (ICN) 0,591 Nd

Dexamethasone, 750 mg / Tablet Dexasone (ICN) 0,589 Nd

Dextrometorphan, bromhydrate

Sugar free, 3 mg/ml / Liquid Balminil DM (Rougier) 1,40 Nd

Dextrometorphan, bromhydrate – pseudoephedrine – guaifenesin,

3 mg-6 mg-20 mg /ml / Liquid Novahistex DM Expt Dcgt (Hoechst Marion Roussel)2,60 Nd

Dextrometorphan, bromhydrate – pseudoephedrine,

1,5 mg-3 mg/ml / Liquid Novahistine DM Dcgt (Hoechst Marion Roussel) 3,00 Nd

Dextrometorphan, bromhydrate – pseudoephedrine,

3 mg-6 mg /ml / Liquid Novahistex DM Dcgt (Hoechst Marion Roussel) 2,40 Nd

Dextrometorphan, bromhydrate, 3 mg/ml / Liquid Balminil DM (Rougier) 2,40 Nd

Dextrometorphan, bromhydrate, 3 mg/ml / Liquid Novahistex DM (Hoechst Marion Roussel) 2,40 Nd

Dextrometorphan, bromhydrate de – pseudoephedrine –

guaifenesin, 1,5 mg-3 mg-10 mg /ml / Liquid Novahistine DM Expt Dcgt (Hoechst Marion Roussel)2,44 Nd

Volume 28, No. 4 – November 2001

THE CANADIAN JOURNALOF NEUROLOGICAL SCIENCES

Drug, concentration and presentation Commercial name and company Caloric content* Caloric content*

– CH§ (Kcal) – Total (Kcal)

Dextrometorphan, bromhydrate, 1,5 mg/ml / Liquid Novahistine DM (Hoechst Marion Roussel) 3,00 Nd

Diazepam, 1 mg/ml / Liquid Pms-diazepam (Pharmascience) 1,38 Nd

Diazepam, 10 mg / Tablet Apo-Diazepam (Apotex) Nd 0,59

Diazepam, 10 mg / Tablet Valium Roche Oral (Hoffman-La Roche) Nd 0,7

Diazepam, 2 mg / Tablet Apo-Diazepam (Apotex) Nd 0,62

Diazepam, 2 mg / Tablet Vivol (Carter Horner) Nd 0,4

Diazepam, 2 mg / Tablet Novo-Dipam (Novopharm) 0,710 0,744

Diazepam, 5 mg / Tablet Apo-Diazepam (Apotex) Nd 0,61

Diazepam, 5 mg / Tablet Valium Roche Oral (Hoffman-La Roche) Nd 0,7

Diazepam, 5 mg / Tablet Novo-Dipam (Novopharm) 0,695 0,712

Diclofenac, 100 mg / Tablet Novo-Difenac SR (Novopharm) 0,878 0,900

Diclofenac, 25 mg / Tablet Novo-Difenac (Novopharm) 0,129 0,135

Diclofenac, 50 mg / Tablet Novo-Difenac (Novopharm) 0,109 0,116

Diclofenac, 75 mg / Tablet Novo-Difenac SR (Novopharm) 0,658 0,675

Dicyclomine, 10 mg / Tablet Bentylol (Hoechst Marion Roussel) 0,369 Nd

Dicyclomine, 2 mg/ml / Liquid Bentylol (Hoechst Marion Roussel) 4,00 Nd

Dicyclomine, 20 mg / Tablet Bentylol (Hoechst Marion Roussel) 0,369 Nd

Diflunisal, 250 mg / Tablet Novo-Diflunisal (Novopharm) 0,125 0,155

Diflunisal, 500 mg / Tablet Novo-Diflunisal (Novopharm) 0,250 0,311

Digoxin, 0,05 mg/ml / Liquid Lanoxin (Glaxo Wellcome) 1,93 2,30

Diltiazem, 120 mg / Tablet Novo-Diltazem SR (Novopharm) 0,00 0,00

Diltiazem, 30 mg / Tablet Novo-Diltazem (Novopharm) 0,623 0,641

Diltiazem, 60 mg / Tablet Novo-Diltazem SR (Novopharm) 0,00 0,00

Diltiazem, 60 mg / Tablet Novo-Diltazem (Novopharm) 1,246 1,282

Diltiazem, 90 mg / Tablet Novo-Diltazem SR (Novopharm) 0,00 0,00

Dimenhydrinate, 15 mg / Tablet Gravol (Carter Horner) Nd 0,20

Dimenhydrinate, 15 mg / Chewable tablet Gravol (Carter Horner) Nd 1,40

Dimenhydrinate, 25 mg / Tablet Gravol (Carter Horner) Nd 0,30

Dimenhydrinate, 25 mg immediate + 50 mg slow release/Capsule Gravol (Carter Horner) 1,20

Dimenhydrinate, 3 mg/ml / Liquid Gravol (Carter Horner) Nd 2,94

Dimenhydrinate, 3 mg/ml / Liquid Pms-dimenhydrinate (Pharmascience) 1,5 Nd

Dimenhydrinate, 50 mg / Tablet Gravol (Carter Horner) Nd 1,40

Dimenhydrinate, 50 mg / Chewable tablet Gravol (Carter Horner) Nd 2,60

Diphenhydramine, 2,5 mg/ml / Liquid Benadryl elixir (Wa r n e r- L a m b e r t ) Nd 2,04

Diphenhydramine, 2,5 mg/ml / Liquid Pms-diphenydramine (Pharmascience) 1,7 Nd

Diphenhydramine, 6,25 mg/ml / Liquid Benadryl (Warner-Lambert) Nd 1,57

Dipyridamole, 100 mg / Tablet Novo-Dipiradol (Novopharm) 0,088 0,479

Dipyridamole, 25 mg / Tablet Novo-Dipiradol (Novopharm) 0,022 0,153

Dipyridamole, 50 mg / Tablet Novo-Dipiradol (Novopharm) 0,044 0,293

Dipyridamole, 75 mg / Tablet Novo-Dipiradol (Novopharm) 0,066 0,379

Divalproex sodium, 125 mg / Tablet Epival (Abbot) 0,08 Nd

Divalproex sodium, 250 mg / Tablet Epival (Abbot) 0,17 Nd

Divalproex sodium, 500 mg / Tablet Epival (Abbot) 0,33 Nd

Docusate calcium, 240 mg / Capsule Surfak (Hoechst Marion Roussel) 0,555 Nd

Docusate, calcium, 240 mg / Capsule Pms-Docusate Calcium (Pharmascience) 1,00 Nd

Docusate, calcium, 240 mg / Capsule Soflax C (Pharmascience) 1,00 Nd

Docusa, sodium + casanthranol, 100 mg + 30 mg / Capsule Peri-Colace (Roberts Pharmaceutical) 1,00 Nd

Docusate, sodium + sennosides, 50 mg + 8,6 mg / Tablet Senokot-S (Purdue Frederick) Nd 0,11

Docusate, sodium, 10 mg/ml / Liquid Colace (Roberts Pharmaceutical) Nd 2,40

Docusate, sodium, 10 mg/ml / Liquid Pms-docusate sodium (Pharmascience) 1,7 Nd

Docusate, sodium, 100 mg / Capsule Pms-docusate sodium (Pharmascience) 0,51 Nd

Docusate, sodium, 100 mg / Capsule Soflax (Pharmascience) 0,51 Nd

Docusate, sodium, 100 mg / Capsule Colace (Roberts Pharmaceutical) 1,00 Nd

Docusate, sodium, 200 mg / Capsule Soflax (Pharmascience) 0,51 Nd

LE JOURNAL CANADIEN DES SCIENCES NEUROLOGIQUES

Drug, concentration and presentation Commercial name and company Caloric content* Caloric content*

– CH§ (Kcal) – Total (Kcal)

Docusate, sodium, 4 mg/ml / Liquid Docusate de sodium (Technilab) Nd 2,78

Docusate, sodium, 4 mg/ml / Liquid Docusate Sodic (Taro Pharmaceuticals) Nd 2,40

Docusate, sodium, 4 mg/ml / Liquid Pms-docusate sodium (Pharmascience) 1,7 Nd

Docusate, sodium, 4 mg/ml / Liquid Colace (Roberts Pharmaceutical) 2,40 Nd

Docusate, sodium, 4 mg/ml / Liquid Docusate sodium syrup (Altas Laboratories) 2,40 Nd

Docusate, sodium, 50 mg/ml / Liquid Pms-docusate sodium (Pharmascience) 1,05 Nd

Doxepin HCl, 100 mg / Capsule Novo-Doxepine (Novopharm) 0,772 0,819

Doxepin HCl, 150 mg / Capsule Novo-Doxepine (Novopharm) 0,923 0,990

Doxepin HCl, 25 mg / Capsule Novo-Doxepine (Novopharm) 0,428 0,452

Doxepin HCl, 50 mg / Capsule Novo-Doxepine (Novopharm) 0,694 0,735

Doxepin HCl, 75 mg / Capsule Novo-Doxepine (Novopharm) 0,568 0,608

Doxycycline, hyclate, 100 mg / Capsule Apo-Doxy (Apotex) Nd 0,74

Doxycycline, hyclate, 100 mg / Capsule Nu-Doxycycline (Nu-Pharm) Nd 0,74

Doxycycline, hyclate, 100 mg / Capsule Novo-Doxylin (Novopharm) 0,022 0,052

Doxycycline, hyclate, 100 mg / Capsule Vibramycin (Pfizer) 0,956 Nd

Doxycycline, hyclate, 100 mg / Tablet Apo-Doxy (Apotex) Nd 0,44

Doxycycline, hyclate, 100 mg / Tablet Nu-Doxycycline (Nu-Pharm) Nd 0,44

Doxycycline, hyclate, 100 mg / Tablet Vibra-Tabs (Pfizer) 0,516 Nd

Erythromycin base, 25 mg/ml / Liquid Erythrocin (Abbot) Nd 1,96

Erythromycin base, 250 mg / Capsule Apo-Erythro E.C. (Apotex) Nd 0,20

Erythromycin base, 250 mg / Capsule Novo-Rythro Encap (Novopharm) 0,198 Nd

Erythromycin base, 250 mg / Tablet Apo-Erythro Base (Apotex) Nd 1,34

Erythromycin base, 250 mg / Tablet Erythromid (Abbott Laboratories) 0,00 Nd

Erythromycin base, 333 mg / Capsule Eryc (Parke-Davis) Nd 0,13

Erythromycin base, 333 mg / Capsule Apo-Erythro E.C. (Apotex) 0,473 Nd

Erythromycin base, 333 mg / Tablet PCE (Laboratoires Abbott Laboratories) 0,64 Nd

Erythromycin base, 50 mg/ml / Liquid Erythrocin (Abbot) Nd 1,84

Erythromycin base, 500 mg / Tablet Erybid (Abbott Laboratories) 0,00 Nd

Erythromycin, estolate, 25 mg/ml / Liquid Ilosone (Eli Lilly) Nd 1,8

Erythromycin, estolate, 50 mg/ml / Liquid Ilosone (Eli Lilly) Nd 1,42

Erythromycin, estolate, 25 mg/ml / Liquid Novo-rythro estolate (Novopharm) 1,37 1,37

Erythromycin, estolate, 250 mg / Capsule Novo-Rythro Estolate (Novopharm) 0,266 0,330

Erythromycin, estolate, 50 mg/ml / Liquid Novo-rythro estolate (Novopharm) 1,37 1,37

Erythromycin, stearate, 25 mg/ml / Liquid Erythrocin (Abbott Laboratories) Nd 1,96

Erythromycin, stearate, 250 mg / Tablet Apo-Erythro S (Apotex) Nd 0,87

Erythromycin, stearate, 250 mg / Tablet Nu-Erythromycin-S (Nu-Pharm) Nd 0,87

Erythromycin, stearate, 250 mg / Tablet Novo-Rythro Stearate (Novopharm) 0,185 1,846

Erythromycin, stearate, 50 mg/ml / Liquid Erythrocin (Abbott Laboratories) Nd 1,84

Erythromycin, stearate, 500 mg / Tablet Apo-Erythro S (Apotex) Nd 1,73

Erythromycin, succinate, 40 mg/ml / Liquid EES 200 (Abbott Laboratories) 2,63 Nd

Erythromycin, succinate, 600 mg / Tablet Apo-Erythro-ES (Apotex) Nd 1,39

Erythromycin, succinate, 600 mg / Tablet EES 600 (Abbott Laboratories) 0,17 Nd

Erythromycin, succinate, 80 mg/ml / Liquid EES 400 (Abbott Laboratories) 2,43 Nd

Erythromycin, succinate, 40 mg/ml / Liquid Novo-rythro ethyl succinate (Novopharm) 1,96 1,96

Erythromycin, succinate, 80 mg/ml / Liquid Novo-rythro ethyl succinate (Novopharm) 1,76 1,76

Erythromycine-sulfisoxazole, 40-120 mg/ml / Liquid Pediazole (Abbot) Nd 1,50

Ethosuximide, 50 mg/ml / Liquid Zarontin (Parke-Davis) Nd 3,00

Famotidine, 10 mg / Tablet Novo-Famotidine (Novopharm) 0,066 0,075

Famotidine, 20 mg / Tablet Novo-Famotidine (Novopharm) 0,132 0,149

Famotidine, 40 mg / Tablet Novo-Famotidine (Novopharm) 0,132 0,149

Fenofibrate, 100 mg / Capsule Novo-Fenofibrate (Novopharm) 0,554 0,566

Ferrous sulfate, 15 mg(element. iron)/ml / Liquid Pms-ferrous sulfate (Pharmascience) 2,71 Nd

Ferrous sulfate, 15 mg(element. iron)/ml / Liquid Fer-In-Sol (Mead Johnson) 2,76 Nd

Ferrous sulfate, 300 mg / Tablet Apo-sulfate ferreux (Apotex) Nd 0,30

Volume 28, No. 4 – November 2001 331

THE CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES

Drug, concentration and presentation Commercial name and company Caloric content* Caloric content*

– CH§ (Kcal) – Total (Kcal)

Ferrous sulfate, 300 mg / Tablet Pms-sulfate ferreux (Pharmascience) 0,57 Nd

Ferrous sulfate, 6 mg(element. iron)/ml / Liquid Pms-ferrous sulfate (Pharmascience) 1,22 Nd

Ferrous sulfate, 6 mg(element. iron)/ml / Liquid Fer-In-Sol (Mead Johnson) 5,00 Nd

Fluconazole, 10 mg/ml / Liquid Diflucan (Pfizer) 2,72 Nd

Flunarizine HCl, 5 mg / Capsule Novo-Flunarizine (Novopharm) 0,576 0,583

Fluorure sodium, 5,56 mg/ml / Liquid Fluor-A-Day (Pharmascience) 0 Nd

Fluoxetine, 4 mg/ml / Liquid Prozac (Eli Lilly) Nd 2,40

Fluoxetine, 10 mg / Capsule Novo-Fluoxetine (Novopharm) 0,730 0,747

Fluoxetine, 20 mg / Capsule Novo-Fluoxetine (Novopharm) 0,694 0,710

Fluoxetine, 4 mg/ml / Liquid Apo-fluoxetine (Apotex) 3,64 Nd

Fluphenazine, 0,5 mg/ml / Liquid Pms-fluphenazine (Pharmascience) 2,39 Nd

Flurazepam, 15 mg / Capsule Novo-Flupam / Novo-Flupam SP.C. (Novopharm) 1,193 1,236

Flurazepam, 30 mg / Capsule Novo-Flupam / Novo-Flupam SP.C. (Novopharm) 1,060 1,103

Flurbiprofen, 100 mg / Tablet Novo-Flurprofen (Novopharm) 0,368 0,401

Flurbiprofen, 50 mg / Tablet Novo-Flurprofen (Novopharm) 0,299 0,322

Flutamide, 250 mg / Tablet Novo-Flutamide (Novopharm) 1,249 1,311

Furosemide, 10 mg/ml / Liquid Lasix (Hoechst Marion Roussel) 1,913 Nd

Furosemide, 20 mg / Tablet Novo-Semide (Novopharm) 0,179 0,187

Furosemide, 20 mg / Tablet Lasix (Hoechst Marion Roussel) 0,211 Nd

Furosemide, 40 mg / Tablet Novo-Semide (Novopharm) 0,360 0,377

Furosemide, 40 mg / Tablet Lasix (Hoechst Marion Roussel) 0,420 Nd

Furosemide, 500 mg / Tablet Lasix special (Hoechst Marion Roussel) 0,466 Nd

Furosemide, 80 mg / Tablet Novo-Semide (Novopharm) 0,719 0,751

Furosemide, 80 mg / Tablet Lasix (Hoechst Marion Roussel) 0,840 Nd

Fusidic acid, 250 mg / Tablet Fucidin (Leo Pharma) Nd 0,29

Fusidic acid, 49,2 mg/ ml / Liquid Fucidin (Leo Pharma) Nd 0,37

Fusidic acid, 50 mg/ ml / Liquid Fucidin (Leo Pharma) Nd 0,78

Gemfibrozil, 300 mg / Capsule Novo-Gemfibrozil (Novopharm) 0,546 0,568

Gemfibrozil, 600 mg / Capsule Novo-Gemfibrozil (Novopharm) 0,205 0,259

Glyburide, 2,5 mg / Tablet Novo-Glyburide (Novopharm) 0,052 0,055

Glyburide, 5 mg / Tablet Novo-Glyburide (Novopharm) 0,103 0,110

Grepafloxacin, chlorhydrate, 200 mg / Tablet Raxar (Glaxo Wellcome) 0,00 Nd

Guaifenesine, 20 mg/ml / Liquid Balminil E (Rougier) Nd 1,60

Guaifenesin, 20 mg/ml / Liquid Balminil E sugar free (Rougier) Nd 1,62

Haloperidol, 0,5 mg / Tablet Novo-Peridol (Novopharm) 0,025 0,041

Haloperidol, 1 mg / Tablet Novo-Peridol (Novopharm) 0,025 0,041

Haloperidol, 10 mg / Tablet Novo-Peridol (Novopharm) 0,050 0,082

Haloperidol, 2 mg / Tablet Novo-Peridol (Novopharm) 0,025 0,041

Haloperidol, 2 mg/ml / Liquid Apo-haloperidol (Apotex) Nd 0,01

Haloperidol, 2 mg/ml / Liquid Novo-peridol (Novopharm) 0,00 0,00

Haloperidol, 2 mg/ml / Liquid Pms-haloperidol (Pharmascience) 0,00 0,00

Haloperidol, 20 mg / Tablet Novo-Peridol (Novopharm) 0,050 0,082

Haloperidol, 5 mg / Tablet Novo-Peridol (Novopharm) 0,025 0,041

Hydralazine HCl, 10 mg / Tablet Novo-Hylazin (Novopharm) 0,292 0,301

Hydralazine, 25 mg / Tablet Novo-Hylazin (Novopharm) 0,182 0,189

Hydralazine, 50 mg / Tablet Novo-Hylazin (Novopharm) 0,100 0,106

Hydrochlorothiazide, 25 mg / Tablet Novo-Hydrazide (Novopharm) 0,238 0,247

Hydrochlorothiazide, 50 mg / Tablet Novo-Hydrazide (Novopharm) 0,477 0,495

Hydrochlorothiazide/methyldopa, 250/15 mg / Tablet Novo-Doparil-15 (Novopharm) 0,168 0,211

Hydrochlorothiazide/methyldopa, 250/25 mg / Tablet Novo-Doparil-25 (Novopharm) 0,135 0,178

Hydromorphone HCl, 1 mg/ml / Liquid Dilaudid (Knoll) Nd 2,00

Hydromorphone HCl, 1 mg/ml / Liquid Pms-hydromorphone (Pharmascience) 1,09 Nd

Hydroxyzine, 2 mg/ml / Liquid Atarax (Pfizer) Nd 3,20

Hydroxyzin, 10 mg / Capsule Apo-Hydroxyzine (Apotex) Nd 0,47

LE JOURNAL CANADIEN DES SCIENCES NEUROLOGIQUES

Drug, concentration and presentation Commercial name and company Caloric content* Caloric content*

– CH§ (Kcal) – Total (Kcal)

Hydroxyzine, 10 mg / Capsule Novo-Hydroxyzin (Novopharm) 0,00 1,40

Hydroxyzine, 2 mg/ml / Liquid Pms-hydroxyzine (Pharmascience) 2,37 Nd

Hydroxyzine, 25 mg / Capsule Apo-Hydroxyzine (Apotex) Nd 0,44

Hydroxyzine, 25 mg / Capsule Novo-Hydroxyzin (Novopharm) 0,00 1,30

Hydroxyzine, 50 mg / Capsule Apo-Hydroxyzine (Apotex) Nd 0,44

Hydroxyzine, 50 mg / Capsule Novo-Hydroxyzin (Novopharm) 0,00 1,25

Ibuprofen, 20 mg/ml / Liquid Advil (Whitehall-Robins) 2,76 Nd

Ibuprofen, 200 mg / Tablet Novo-Profen (Novopharm) 0,180 0,215

Ibuprofen, 200 mg / Tablet (sugar coating) Novo-Profen (Novopharm) 0,256 0,291

Ibuprofen, 300 mg / Tablet Novo-Profen (Novopharm) 0,270 0,322

Ibuprofen, 300 mg / Tablet (sugar coating) Novo-Profen (Novopharm) 0,373 0,425

Ibuprofen, 400 mg / Tablet Novo-Profen (Novopharm) 0,360 0,429

Ibuprofen, 400 mg / Tablet (suger coating) Novo-Profen (Novopharm) 0,463 0,532

Ibuprofen, 600 mg / Tablet Novo-Profen (Novopharm) 0,540 0,593

Imipramine, 10 mg / Tablet Novo-Pramine (Novopharm) 0,080 0,088

Imipramine, 25 mg / Tablet Novo-Pramine (Novopharm) 0,080 0,088

Imipramine, 50 mg / Tablet Novo-Pramine (Novopharm) 0,195 0,209

Indapamide, 2,5 mg / Tablet Novo-Indapamide (Novopharm) 0,255 0,260

Indomethacin, 25 mg / Capsule Novo-Methacin / Novo-Methacin SP.C. (Novopharm) 0,887 0,910

Indomethacin, 50 mg / Capsule Novo-Methacin / Novo-Methacin SP.C. (Novopharm) 1,458 1,495

Ioniazid, 10 mg/ml / Liquid Pms-isoniazid (Pharmascience) 0,89 Nd

Isosorbide dinitrate, 10 mg / Tablet Novo-Sorbide (Novopharm) 0,160 0,174

Isosorbide dinitrate, 30 mg / Tablet Novo-Sorbide (Novopharm) 0,420 0,442

Itraconazole, 10 mg/ml / Liquid Sporanox (Jansen-Ortho) 0,50 Nd

Ketoconazole, 20 mg/ml / Liquid Nizoral (Jansen-Ortho) 0,25 Nd

Ketotifen, fumarate, 0,2 mg/ml / Liquid Apo-Ketotifen (Apotex) 2,562 Nd

Ketotifen, fumarate, 0,2 mg/ml / Liquid Novo-Ketotifen (Novopharm) 3,31 3,31

Ketotifen, fumarate, 1 mg / Tablet Novo-Ketotifen (Novopharm) 0,493 0,499

Ketotifen, fumarate, 0,2 mg/ml / Liquid Zaditen (Novartis Pharma) 2,41 Nd

Lactose (placebo) / Capsule Novo-Plus (Novopharm) 0,720 0,732

Lactulose, 666,7 mg/ml / Liquid Gen-lac (Genpharm) Nd 3,64

Lactulose, 666,7 mg/ml / Liquid Pms-lactulose (Pharmascience) 3,5 Nd

Lamivudine, 10 mg/ml / Liquid 3-TC (Glaxo Wellcome) 1,13 1,27

Lamotrigine, 100 mg / Tablet Lamictal (Glaxo Wellcome) 0,428 Nd

Lamotrigine, 150 mg / Tablet Lamictal (Glaxo Wellcome) 0,644 Nd

Lamotrigine, 25 mg / Tablet Lamictal (Glaxo Wellcome) 0,107 Nd

Lidocaine, 2 % / Liquid Pms-lidocaine viscous (Pharmascience) 0,2 Nd

Lithium, carbonate, 60 mg/ml / Liquid Pms-lithium citrate (Pharmascience) 1,77 Nd

Loperamide, 0,2 mg/ml / Liquid Pms-loperamide (Pharmascience) 2,19 Nd

Loperamide, 2 mg / Tablet Novo-Loperamide (Novopharm) 1,353 1,383

Loratadine, 1 mg/ml / Liquid Claritin (Schering) 3,20 Nd

Lorazepam, 0,5 mg / Tablet Apo-Lorazepam (Apotex) Nd 0,19

Lorazepam, 0,5 mg / Tablet (Sublingual) Ativan (Wyeth-Ayerst) Nd 0,14

Lorazepam, 0,5 mg / Tablet Nu-Loraz (Nu-Pharm) Nd 0,19

Lorazepam, 0,5 mg / Tablet Novo-Lorazem (Novopharm) 0,049 0,049

Lorazepam, 1 mg / Tablet Novo-Lorazem (Novopharm) 0,098 0,099

Lorazepam, 1,0 mg / Tablet Apo-Lorazepam (Apotex) Nd 0,38

Lorazepam, 1,0 mg / Tablet (Sublingual) Ativan (Wyeth-Ayerst) Nd 0,59

Lorazepam, 1,0 mg / Tablet Nu-Loraz (Nu-Pharm) Nd 0,38

Lorazepam, 2 mg / Tablet Novo-Lorazem (Novopharm) 0,110 0,112

Lorazepam, 2,0 mg / Tablet Apo-Lorazepam (Apotex) Nd 0,47

Lorazepam, 2,0 mg / Tablet (Sublingual) Ativan (Wyeth-Ayerst) Nd 0,19

Lorazepam, 2,0 mg / Tablet Nu-Loraz (Nu-Pharm) Nd 0,47

Magaldrate, 96 mg/ml / Liquid Riopan (Whitehall-Robins) 0 Nd

Volume 28, No. 4 – November 2001 333

THE CANADIAN JOURNALOF NEUROLOGICAL SCIENCES

Drug, concentration and presentation Commercial name and company Caloric content* Caloric content*

– CH§ (Kcal) – Total (Kcal)

Magnesium, citrate, 15 g/flacon / Liquid Citro-Mag (Rougier) Nd 1,05

Magnesium, hydroxyde, 80 mg/ml / Liquid Lait de magnesie (Atlas laboratories) 0 Nd

Maprotiline HCl, 10 mg / Tablet Novo-Maprotiline (Novopharm) 0,290 0,299

Maprotiline HCl, 50 mg / Tablet Novo-Maprotiline (Novopharm) 0,266 0,279

Maprotiline HCl, 75 mg / Tablet Novo-Maprotiline (Novopharm) 0,366 0,384

Medroxyprogesterone acetate, 10 mg / Tablet Novo-Medrone (Novopharm) 0,428 0,433

Medroxyprogesterone acetate, 2,5 mg / Tablet Novo-Medrone (Novopharm) 0,380 0,384

Medroxyprogesterone acetate, 5 mg / Tablet Novo-Medrone (Novopharm) 0,370 0,374

Meprobamate, 200 mg / Tablet Novo-Mepro (Novopharm) 0,084 0,117

Meprobamate, 400 mg / Tablet Novo-Mepro (Novopharm) 0,168 0,235

Methotrimeprazine maleate, 25 mg / Tablet Novo-Meprazine (Novopharm) 0,023 0,035

Methotrimeprazine maleate, 50 mg / Tablet Novo-Meprazine (Novopharm) 0,104 0,130

Methotrimeprazine, 40 mg/ml / Liquid Nozinan (Rhône-Poulenc Rorer) Nd 1,80

Methotrimeprazine, 5 mg/ml / Liquid Nozinan (Rhône-Poulenc Rorer) Nd 2,98

Methyldopa, 125 mg / Tablet Novo-Medopa (Novopharm) 0,060 0,074

Methyldopa, 250 mg / Tablet Novo-Medopa (Novopharm) 0,119 0,148

Methyldopa, 500 mg / Tablet Novo-Medopa (Novopharm) 0,238 0,297

Metoclopramide, 1 mg/ml / Liquid Pms-metoclopramide (Pharmascience) 1,3 Nd

Metoclopramide, chlorhydrate, 1 mg/ml / Liquid Maxeran (Hoechst Marion Roussel) 1,960 Nd

Metoclopramide, chlorhydrate, 10 mg / Tablet Maxeran (Hoechst Marion Roussel) 0,361 Nd

Metoclopramide, chlorhydrate, 5 mg / Tablet Maxeran (Hoechst Marion Roussel) 0,371 Nd

Metoprolol, 100 mg / Tablet coated Novo-Metoprol (Novopharm) 0,601 0,635

Metoprolol, 100 mg / Tablet uncoated Novo-Metoprol Uncoated (Novopharm) 0,601 0,631

Metoprolol, 50 mg / Tablet coated Novo-Metoprol (Novopharm) 0,509 0,531

Metoprolol, 50 mg / Tablet uncoated Novo-Metoprol Uncoated (Novopharm) 0,301 0,340

Metronidazole, 250 mg / Tablet Apo-Metronidazole (Apotex) Nd 0,95

Metronidazole, 250 mg / Tablet Novo-Nidazole (Novopharm) 0,585 0,620

Metronidazole, 500 mg / Capsule Flagyl (Rhône-Poulenc Rorer) 0,00 Nd

Mexiletine, chlorhydrate, 100 mg / Granules Novo-Mexiletine (Novopharm) 0,192 0,200

Mexiletine, chlorhydrate, 200 mg / Granules Novo-Mexiletine (Novopharm) 0,383 0,401

Mineral oil 78 % sugar free jelly, / Jelly Lansoyl (Jouveinal) Nd 0,27

Mineral oil 78 % jelly, / Jelly Lansoyl (Jouveinal) Nd 0,60

Mineral oil + glycerine, / Liquid Agarol (Warner-Lambert) Nd 0,65

Minocycline, chlorhydrate, 100 mg / Capsule Apo-Minocycline (Apotex) Nd 0,56

Minocycline, chlorhydrate, 100 mg / Capsule Minocin (Wyeth-Ayerst) Nd 1,0

Minocycline, chlorhydrate, 50 mg / Capsule Apo-Minocycline (Apotex) Nd 0,28

Minocycline, chlorhydrate, 50 mg / Capsule Minocin (Wyeth-Ayerst) Nd 1,0

Minocycline, chlorhydrate, 100 mg / Capsule Novo-Minocyline (Novopharm) 0,608 0,625

Minocycline, chlorhydrate, 50 mg / Capsule Novo-Minocyline (Novopharm) 0,524 0,536

Morphine, 1 mg/ml / Liquid Morphitec-1 (Technilab) Nd 2,23

Morphine, 1 mg/ml / Liquid M.O.S. (ICN) 0,21 Nd

Morphine, 10 mg/ml / Liquid Morphitec-10 (Technilab) Nd 2,23

Morphine, 10 mg/ml / Liquid M.O.S. (ICN) 1,00 Nd

Morphine, 20 mg/ml / Liquid Morphitec-20 (Technilab) Nd 2,23

Morphine, 5 mg/ml / Liquid Morphitec-5 (Technilab) Nd 2,23

Morphine, 5 mg/ml / Liquid M.O.S. (ICN) 1,17 Nd

Nadolol, 160 mg / Tablet Novo-Nadolol (Novopharm) 1,228 1,276

Nadolol, 40 mg / Tablet Novo-Nadolol (Novopharm) 0,307 0,320

Nadolol, 80 mg / Tablet Novo-Nadolol (Novopharm) 0,614 0,639

Naproxen, 125 mg / Tablet Novo-Naprox (Novopharm) 0,037 0,061

Naproxen, 25 mg/ml / Liquid Naprosyn (Hoffman-La Roche) 1,16 Nd

Naproxen, 250 mg / Tablet Novo-Naprox (Novopharm) 0,075 0,122

Naproxen, 375 mg / Tablet Novo-Naprox (Novopharm) 0,112 0,183

Naproxen, 500 mg / Tablet Novo-Naprox (Novopharm) 0,149 0,245

LE JOURNAL CANADIEN DES SCIENCES NEUROLOGIQUES

Drug, concentration and presentation Commercial name and company Caloric content* Caloric content*

– CH§ (Kcal) – Total (Kcal)

Naproxen, sodium, 275 mg / Tablet Novo-Naprox Sodium (Novopharm) 0,077 0,135

Naproxen, sodium, 550 mg / Tablet Novo-Naprox Sodium D.S. (Novopharm) 0,154 0,270

Nitrazepam, 10 mg / Tablet Nitrazadon (ICN) 0,47 Nd

Nitrazepam, 10 mg / Tablet Rho-Nitrazepam (Rhodiapharm) 0,47 Nd

Nitrazepam, 10 mg / Tablet Mogadon (Hoffman-La Roche) 0,70 0,80

Nitrazepam, 5 mg / Tablet Nitrazadon (ICN) 0,233 Nd

Nitrazepam, 5 mg / Tablet Rho-Nitrazepam (Rhodiapharm) 0,233 Nd

Nitrazepam, 5 mg / Tablet Mogadon (Hoffman-La Roche) 0,35 0,40

Nitrofurantoin, 100 mg / Tablet Novo-Furan (Novopharm) 0,146 0,172

Nitrofurantoin, 5 mg/ml / Liquid Novo-Furan (Novopharm) 2,25 2,27

Nitrofurantoin, 50 mg / Capsule Novo-Furantoin Capsules (Novopharm) 0,037 0,037

Nitrofurantoin, 50 mg / Tablet Novo-Furan (Novopharm) 0,073 0,086

Norfloxacin, / Tablet Apo-Norflox (Apotex) 0,044 Nd

Norfloxacin, 400 mg / Tablet Noroxin (Merck Sharp & Dohme) 0,00 Nd

Normethadone + ephedrine, 10 mg/ml / Liquid Cophylac (Hoechst Marion Roussel) 0,80 Nd

Nystatin, 100 000 u/ml / Liquid Nilstat (Technilab) 3,00

Nystatin, 100 000 u/ml / Liquid Mycostatin (Bristol-Myers Squibb Gr. Pharma) 2,41 Nd

Nystatin, 100 000 u/ml / Liquid Pms-nystatin (Pharmascience) 2,62 Nd

Nystatin, 100 000 UI/ml / Liquid Nadostine (Nadeau Laboratories) Nd 2,60

Nystatin, 100 000 UI/ml / sugar free Liquid Nadostine (Nadeau Laboratories) Nd 0,42

Nystatin, 500 000 UI / Tablet Nadostine (Nadeau Laboratories) Nd 0,43

Nystatin, 500 000 UI / Tablet Mycostatin (Bristol-Myers Squibb) 0,35 Nd

Ofloxacin, 200 mg / Tablet Apo-Oflox (Apotex) 0,096 Nd

Ofloxacin, 300 mg / Tablet Apo-Oflox (Apotex) 0,15 Nd

Ofloxacin, 400 mg / Tablet Apo-Oflox (Apotex) 0,21 Nd

Orciprenaline, 2 mg/ml / Liquid Alti-orciprenalline (Altimed Pharmaceutical Co.) Nd 0,036

Orciprenaline, 2 mg/ml / Liquid Apo-orciprenaline (Apotex) 1,99 Nd

Oxazepam, 10 mg / Tablet Novoxapam (Novopharm) 0,588 0,613

Oxazepam, 15 mg / Tablet Novoxapam (Novopharm) 0,566 0,584

Oxtriphylline, 10 mg/ml / Liquid Choledyl (Parke-Davis) Nd 3,66

Oxtriphylline, 100 mg / Tablet Novo-Triphyl (Novopharm) 0,104 0,170

Oxtriphylline, 20 mg/ml / Liquid Choledyl (Parke-Davis) Nd 2,80

Oxtriphylline, 200 mg / Tablet Novo-Triphyl (Novopharm) 0,134 0,220

Oxtriphylline, 300 mg / Tablet Novo-Triphyl (Novopharm) 0,136 0,224

Oxybutinin, 1 mg/ml / Liquid Apo-oxybutinin (Apotex) 2,81 Nd

Oxybutinin, 1 mg/ml / Liquid Ditropan (Procter & Gamble) 1,01 Nd

Oxybutinin, 5 mg / Tablet Novo-Oxybutinin (Novopharm) 0,601 0,616

Penicilline G, 500 000 U.I. / Tablet Novo-Pen G-500 (Novopharm) 0,104 0,171

Penicillin VK, 25 mg/ml / Liquid Apo-pen VK (Apotex) Nd 0,81

Penicillin VK, 300 mg / Tablet Apo-Pen VK (Apotex) Nd 0,09

Penicillin VK, 500 000 U.I. / Tablet Novo-Pen VK (Novopharm) 0,501 0,573

Penicillin VK, 60 mg/ml / Liquid Apo-pen VK (Apotex) Nd 2,50

Penicillin VK, 60 mg/ml / Liquid Novo-Pen VK (Novopharm) 2,028 2,112

Pericyazin, 10 mg/ml / Liquid Neuleptil (Rhône-Poulenc Rorer) Nd 1,00

Phenobarbital, 100 mg / Capsule Novo-Pentobarb (Novopharm) 0,227 0,254

Phenobarbital, 15 mg / Tablet Phenobarbital (Parke-Davis) 0,24 0,24

Phenobarbital, 30 mg / Tablet Phenobarbital (Parke-Davis) 0,33 0,33

Phenobarbital, 5 mg/ml / Liquid Pnenobarbital elixir USP(Stanley Pharmaceuticals) 3,78 Nd

Phenobarbital, 60 mg / Tablet Phenobarbital (Parke-Davis) 0,35 0,35

Phenylbutazone, 100 mg / Tablet Novo-Butazone (Novopharm) 0,053 0,060

Phenylephrine HCl – hydrocodone bitartrate – guaifenesin,

4 mg-1 mg-40 mg /ml / Liquid Novahistex DH Expt (Hoechst Marion Roussel) 3,00 Nd

Phenylephrine HCl – hydrocodone bitartrate,

2 mg-0,34 mg /ml / Liquid Novahistine DH (Hoechst Marion Roussel) 1,38 Nd

Volume 28, No. 4 – November 2001 335

THE CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES

Drug, concentration and presentation Commercial name and company Caloric content* Caloric content*

– CH§ (Kcal) – Total (Kcal)

Phenylephrine HCl – hydrocodone bitartrate,

4 mg-1 mg /ml / Liquid Novahistex DH (Hoechst Marion Roussel) 2,42 Nd

Phenylephrine HCl – codeine phosphate,

4 mg-3 mg /ml / Liquid Novahistex C (Hoechst Marion Roussel) 2,22 Nd

Phenytoin sodium, 100 mg / Capsule Dilantin (Parke-Davis) 0,48 0,60

Phenytoin sodium, 30 mg / Capsule Dilantin (Parke-Davis) Nd 0,70

Phenytoin, 25 mg/ml / Liquid Dilantin-125 (Parke-Davis) 1,14 Nd

Phenytoin, 50 mg / Tablet Dilantin Infatabs (Parke-Davis) 1,92 Nd

Pindolol, 10 mg / Tablet Novo-Pindol (Novopharm) 0,055 0,063

Pindolol, 15 mg / Tablet Novo-Pindol (Novopharm) 0,083 0,094

Pindolol, 5 mg / Tablet Novo-Pindol (Novopharm) 0,050 0,056

Piroxicam, 10 mg / Capsule Novo-Pirocam (Novopharm) 1,056 1,086

Piroxicam, 20 mg / Capsule Novo-Pirocam (Novopharm) 1,056 1,086

Pivampicillin, 35 mg/ml / Liquid Pondocillin (Leo Pharma) 1,62 1,62

Pivampicillin, 500 mg / Tablet Pondocillin (Leo Pharma) 0,43 0,43

Pivmecillinam, chlorhydrate, 200 mg / Tablet Selaxid (Leo Pharma) 0,00 Nd

Polyethylene glycol /electrolytes, / Liquid Lyteprep (Therapex) 0,00 Nd

Polyethylen glycol /electrolytes, / Liquid Colyte (Reed & Carnrick) 0,00 Nd

Polyethylen glycol /electrolytes, / Liquid PegLyte (Pharmascience) 0,00 Nd

Polyethylen glycol /electrolytes, / Powder PegLyte (Pharmascience) 0,00 Nd

Polystyrene sulfonate / Liquid Novo-Prazin (Novopharm) 0,202 0,208

Prazocin HCl, 2 mg / Tablet Novo-Prazin (Novopharm) 0,253 0,260

Prazocin HCl, 5 mg / Tablet Novo-Prazin (Novopharm) 0,471 0,484

Prednisolone, 1 mg/ml / Liquid Pediapred (Rhône-Poulenc Rorer) 2,26 Nd

Prednisolone, 5 mg / Tablet Novo-Prednisolone (Novopharm) 0,262 0,273

Prednisone, 5 mg / Tablet Novo-Prednisone (Novopharm) 0,510 0,520

Prednisone, 50 mg / Tablet Novo-Prednisone (Novopharm) 0,586 0,606

Primidone, 125 mg / Chewtab Mysoline (Wyeth-Ayerst) Nd 0,12

Primidone, 125 mg / Tablet Apo-Primidone (Apotex) Nd 0,17

Primidone, 250 mg / Comrime Mysoline (Wyeth-Ayerst) Nd 0,23

Primidone, 250 mg / Tablet Apo-Primidone (Apotex) Nd 0,34

Prochlorperazine, 1 mg/ml / Liquid Stemetil (Rhône-Poulenc Rorer) 3,18 Nd

Prochlorperazine, 10 mg / Tablet Stemetil (Rhône-Poulenc Rorer) 0 Nd

Prochlorperazine, 5 mg / Tablet Stemetil (Rhône-Poulenc Rorer) 0 Nd

Procyclidine, 0,5 mg/ml / Liquid Pms-procyclidine (Pharmascience) 1,16 Nd

Procyclidine, 0,5 mg/ml / Liquid Kemadrin (Glaxo Wellcome) 2,30 Nd

Procyclidine, 5 mg / Tablet Kemadrin (Glaxo Wellcome) 0,47 Nd

Promethazine, 2 mg/ml / Liquid Pms-promethazine (Pharmascience) 1,8 Nd

Propoxyphene, hydrochloride, 65 mg / Capsule Novo-Propoxyn (Novopharm) 0,491 0,504

Propranolol, 10 mg / Tablet Novo-Pranol (Novopharm) 0,434 0,451

Propranolol, 120 mg / Tablet Novo-Pranol (Novopharm) 1,196 1,240

Propranolol, 20 mg / Tablet Novo-Pranol (Novopharm) 0,352 0,374

Propranolol, 40 mg / Tablet Novo-Pranol (Novopharm) 0,704 0,725

Propranolol, 80 mg / Tablet Novo-Pranol (Novopharm) 0,819 0,861

Prpoxyphen HCl-ASA-caffeine, / Capsule Novo-Propoxyn Compound (Novopharm) 0,371 0,396

Pseudoephedrine, 6 mg/ml / Liquid Balminil Decongestant (Rougier) Nd 1,88

Pseudoephedrine, 6 mg/ml / Liquid Pms-pseudoephedrine (Pharmascience) 3,70 Nd

Psyllium no flavor, / Powder Novo-Mucilax (Novopharm) 1,983/g 1,983/g

Psyllium no sugar, / Powder Novo-Mucilax (Novopharm) 0,000/g 0,000/g

Psyllium orange flavor / Powder Novo-Mucilax (Novopharm) 1,617/g 1,617/g

Psyllium orange, smooth texture / Powder Metamucil (Procter & Gamble) 7,76 /g 7,76 /g

Psyllium (hydrophilic mucilloid for oral suspension)

orange – smooth texture “Sugar free”, / Powder Metamucil (Procter & Gamble) 3,45 /g 3,45 /g

Psyllium no flavor, / Powder Metamucil (Procter & Gamble) 1,98 /g 1,98 /g

LE JOURNAL CANADIEN DES SCIENCES NEUROLOGIQUES

Drug, concentration and presentation Commercial name and company Caloric content* Caloric content*

– CH§ (Kcal) – Total (Kcal)

Psyllium no flavor, no sugar, smooth texture, / Powder Metamucil (Procter & Gamble) 3,45 /g 3,45 /g

Psyllium + sene, / Granules Prodiem Plus (Novartis) Nd 0,74/g

Psyllium / Granules Prodiem Simple (Novartis) Nd 0,72/g

Pyrantel pamoate, 50 mg/ml / Liquid Combantrin (Pfizer) 3,24 Nd

Pyridoxine hydrochloride, 25 mg / Tablet Vitamine B6 (Wampole) 0,00 Nd

Pyrvinium pamoate, 10 mg/ml / Liquid Vanquin (Warner-Lambert) Nd 0,90

Quinidine, 200 mg / Tablet Novo-Quinidine (Novopharm) 0,127 0,228

Quinine, 200 mg / Capsule Novo-Quinine (Novopharm) 0,428 0,536

Ranitidine, 15 mg/ml / Liquid Zantac (Glaxo Wellcome) 0,80 0,83

Ranitidine, 150 mg / Tablet Novo-Ranidine (Novopharm) 0,00 0,138

Ranitidine, 150 mg / Tablet Zantac (Glaxo Wellcome) 0,01 Nd

Ranitidine, 300 mg / Tablet Novo-Ranidine (Novopharm) 0,00 0,276

Ranitidine, 300 mg / Tablet Zantac (Glaxo Wellcome) 0,01 Nd

Reserpine, 0,25 mg / Tablet Novo-Reserpine (Novopharm) 0,607 0,613

Rifampin, 150 mg / Capsule Rifadin (Hoechst Marion Roussel) 0,091 Nd

Rifampin, 300 mg / Capsule Rifadin (Hoechst Marion Roussel) 0,181 Nd

Salbutamol, 0,4 mg/ml / Liquid Ventolin (Glaxo Wellcome) 0,03 0,03

Salbutamol, 2 mg / Tablet Novo-Salmol (Novopharm) 0,415 0,430

Salbutamol, 4 mg / Tablet Novo-Salmol (Novopharm) 0,829 0,860

Secobarbital sodium, 100 mg / Capsule Novo-Secobarb (Novopharm) 0,385 0,424

Selegiline, 5 mg / Tablet Novo-Selegiline (Novopharm) 0,487 0,514

Sennosides, 1,7 mg/ml / Liquid Senokot (Purdue Frederick) Nd 3,04

Sennosides, 15 mg/5 ml (3g) / Granules Senokot (Purdue Frederick) Nd 2,93/g

Sennosides, 8,6 mg / Tablet Senokot (Purdue Frederick) Nd 0,22

Sennosides, 119 mg /dose unit (70ml) / Liquid X-Prep (Purdue Frederick) Nd 212 / 70 ml

bottle

Sennosides, 12 mg / Dragee Glysennid (Novartis) Nd 0,36

Sennosides, 12 mg / Tablet Pms-Sennosides (Pharmascience) 0,04 Nd

Sennosides, 15 mg / Chocolate Ex-Lax, chocolate pieces (Novartis) 1,80 Nd

Sennosides, 15 mg / Tablet Ex-Lax, sugar coated tablets (Novartis) 0,74 Nd

Sennosides, 157,5 mg (21g) / Powder X-Prep (Purdue Frederick) Nd 38/sachet

Sennosides, 25 mg / Tablet Ex-Lax extra-strong, sugar coated tablets (Novartis) 0,74 Nd

Sennosides, 8,6 mg / Dragee Glysennid (Novartis) Nd 0,34

Sennosides, 8,6 mg / Tablet Pms-Sennosides (Pharmascience) 0,06 Nd

Simethicone, 40 mg/ml / Liquid Ovol (Carter Horner) Nd 0,30

Sodium citrate + citric acid, 1 meq/ml / Liquid Pms-dicitrate sodium (Pharmascience) 0 Nd

Sodium phosphates, 2,4g monobasic + 0,9g dibasic /5ml / Liquid Fleet Phospho-Soda (Johnson & Jonhson Merck) 0,05 Nd

Sodium phosphates, 2,4g monobasic + 0,9g dibasic /5ml / Liquid Pms-phosphate solution (Pharmascience) 0,2 Nd

Sotalol HCl, 80 mg / Tablet Novo-Stalol (Novopharm) 0,241 0,253

Spiramycine, 250 mg / Capsule Rovamycine (Rhône-Poulenc Rorer) 0,92 Nd

Spiramycine, 500 mg / Capsule Rovamycine (Rhône-Poulenc Rorer) 1,84 Nd

Spironolactone / hydrochlorothiazide, 25/25 mg / Tablet Novo-Spirozine (Novopharm) 1,154 1,188

Spironolactone / hydrochlorothiazide, 50/50 mg / Tablet Novo-Spirozine (Novopharm) 2,308 2,377

Spironolactone, 100 mg / Tablet Novo-Spiroton (Novopharm) 2,042 2,126

Spironolactone, 25 mg / Tablet Novo-Spiroton (Novopharm) 0,895 0,929

Stavudine, 1 mg/ml / Liquid Zerit (Bristol-Myers Squibb) 0,195 Nd

Stavudine, 15 mg / Capsule Zerit (Bristol-Myers Squibb) 0,514 Nd

Stavudine, 20 mg / Capsule Zerit (Bristol-Myers Squibb) 0,772 Nd

Stavudine, 30 mg / Capsule Zerit (Bristol-Myers Squibb) 0,772 Nd

Stavudine, 40 mg / Capsule Zerit (Bristol-Myers Squibb) 1,02 Nd

Sucralfate, 1000 mg / Tablet Sulcrate (Hoechst Marion Roussel) 0,00 Nd

Sucralfate, 1000 mg / Tablet Novo-Sucralate (Novopharm) 0,144 0,247

Sucralfate, 200 mg/ml / Liquid Sulcrate Suspension Plus (Hoechst Marion Roussel) 1,04 Nd

Sulfapyridine, 500 mg / Tablet Dagenan (Rhône-Poulenc Rorer) 2,053 Nd

Volume 28, No. 4 – November 2001

THE CANADIAN JOURNALOF NEUROLOGICAL SCIENCES

Drug, concentration and presentation Commercial name and company Caloric content* Caloric content*

– CH§ (Kcal) – Total (Kcal)

Sulfinpyrazone, 100 mg / Tablet Novo-Pyrazone (Novopharm) 0,060 0,086

Sulfinpyrazone, 200 mg / Tablet Novo-Pyrazone (Novopharm) 0,603 0,629

Sulfisoxazole, 500 mg / Tablet Novo-Soxazole (Novopharm) 0,518 0,616

Pms-sodium polystyren sulfonate (Pharmascience) 0,94 Nd

Sulindac, 150 mg / Tablet Novo-Sundac (Novopharm) 0,055 0,094

Sulindac, 200 mg / Tablet Novo-Sundac (Novopharm) 0,102 0,126

Temazepam, 15 mg / Capsule Novo-Temazepam (Novopharm) 0,781 0,795

Tenoxicam, 20 mg / Tablet Novo-Tenoxicam (Novopharm) 0,635 0,645

Terfenadine, 120 mg / Tablet Seldane (Hoechst Marion Roussel) 1,732 Nd

Terfenadine, 6 mg/ml / Liquid Seldane (Hoechst Marion Roussel) 1,44 Nd

Terfenadine, 60 mg / Tablet Seldane (Hoechst Marion Roussel) 0,198 Nd

Terfenadine, 60 mg / Tablet Novo-Terfenadine (Novopharm) 1,453 1,483

Tetracycline, 25 mg/ml / Liquid Novo-Tetra (Novopharm) 1,98 1,98

Tetracycline, 250 mg / Capsule Novo-Tetra (Novopharm) 0,163 0,217

Tetracycline, 250 mg / Tablet Novo-Tetra (Novopharm) 0,064 0,110

Tetracycline, chlorhydrate, 250 mg / Capsule Apo-Tetra (Apotex) Nd 0,21

Tetracycline, chlorhydrate, 250 mg / Capsule Nu-Tetra (Nu-Pharm) Nd 0,21

Theophylline, 5,33 mg/ml / Liquid Theophylline, elixir (Rougier) Nd 2,82

Theophylline, 5,33 mg/ml / Liquid Theolair (3M Pharmaceutical Products) 2,38 Nd

Theophylline anhydrous, 100 mg / Tablet Novo-Theophyl SR (Novopharm) 0,00 0,003

Thioridazine, 10 mg / Tablet Novo-Ridazine (Novopharm) 0,194 0,204

Thioridazine, 100 mg / Tablet Novo-Ridazine (Novopharm) 0,083 0,117

Thioridazine, 2 mg/ml / Liquid Mellaril suspension (Novartis pharma) 2,27 Nd

Thioridazine, 200 mg / Tablet Novo-Ridazine (Novopharm) 0,080 0,106

Thioridazine, 25 mg / Tablet Novo-Ridazine (Novopharm) 0,082 0,093

Thioridazine, 30 mg/ml / Liquid Mellaril solution (Novartis pharma) 1,23 Nd

Thioridazine, 50 mg / Tablet Novo-Ridazine (Novopharm) 0,103 0,133

Tiaprofenic, acid, 200 mg / Tablet Novo-Tiaprofenic (Novopharm) 0,039 0,061

Tiaprofenic, acid, 300 mg / Tablet Novo-Tiaprofenic (Novopharm) 0,059 0,092

Timolol, maleate, 10 mg / Tablet Novo-Timol (Novopharm) 0,213 0,228

Timolol, maleate, 20 mg / Tablet Novo-Timol (Novopharm) 0,427 0,456

Timolol, maleate, 5 mg / Tablet Novo-Timol (Novopharm) 0,107 0,114

Tolbutamide, 500 mg / Tablet Novo-Butamide SP.C. (Novopharm) 0,527 0,615

Tolbutamide, 500 mg / Tablet Novo-Butamide (Novopharm) 0,532 0,613

Tolmetine sodic, 400 mg / Capsule Novo-Tolmetin (Novopharm) 0,303 0,329

Topiramate, 100 mg / Tablet Topamax (Jansen-Ortho) 0,642 Nd

Topiramate, 200 mg / Tablet Topamax (Jansen-Ortho) 0,350 Nd

Topiramate, 25 mg / Tablet Topamax (Jansen-Ortho) 0,161 Nd

Trazadone, 100 mg / Tablet Novo-Trazadone (Novopharm) 0,604 0,638

Trazadone, 150 mg / Tablet Novo-Trazadone (Novopharm) 0,147 0,163

Trazadone, 50 mg / Tablet Novo-Trazadone (Novopharm) 0,301 0,318

Triamterene / Hydrochlorothiazide, 50/25 mg / Tablet Novo-Triamzide (Novopharm) 0,060 0,091

Triazolam, 0,125 mg / Tablet Novo-Triolam (Novopharm) 0,312 0,320

Triazolam, 0,25 mg / Tablet Novo-Triolam (Novopharm) 0,310 0,319

Trifluoperazine, 1 mg / Tablet Novo-Flurazine (Novopharm) 0,267 0,278

Trifluoperazine, 10 mg / Tablet Novo-Flurazine (Novopharm) 0,520 0,542

Trifluoperazine, 10 mg/ml / Liquid Pms-trifluoperazine (Pharmascience) 2,6 Nd

Trifluoperazine, 2 mg / Tablet Novo-Flurazine (Novopharm) 0,387 0,403

Trifluoperazine, 20 mg / Tablet Novo-Flurazine (Novopharm) 0,523 0,545

Trifluoperazine, 5 mg / Tablet Novo-Flurazine (Novopharm) 0,430 0,447

Trihexyphenidyle, 0,4 mg/ml / Liquid Pms-trihexyphenidyle (Pharmascience) 2,02 Nd

Trihexyphenidyle, 2 mg / Tablet Novo-Hexidyl (Novopharm) 0,056 0,076

Trihexyphenidyle, 5 mg / Tablet Novo-Hexidyl (Novopharm) 0,115 0,155

Trimeprazin, 0,5 mg/ml / Liquid Panectyl 2.5 (Rhône-Poulenc Rorer) 3,22 Nd

LE JOURNAL CANADIEN DES SCIENCES NEUROLOGIQUES

Drug, concentration and presentation Commercial name and company Caloric content* Caloric content*

– CH§ (Kcal) – Total (Kcal)

Trimethoprim + sulfamethoxazole, 160/800 mg / Tablet Apo-sulfatrim DS (Apotex) Nd 0,30

Trimethoprim + sulfamethoxazole, 160/800 mg / Tablet Bactrim Roche (Hoffman-La Roche) Nd 0,40

Trimethoprim + sulfamethoxazole, 160/800 mg / Tablet Nu-Cotrimox (Nu-Pharm) Nd 0,30

Trimethoprim + sulfamethoxazole, 160/800 mg / Tablet Septra DS (Glaxo Wellcome) Nd 0,08

Trimethoprim + sulfamethoxazole, 160/800 mg / Tablet Novo-Trimel (Novopharm) 0,325 0,470

Trimethoprim + sulfamethoxazole, 20/100 mg / Tablet ped. Apo-sulfatrim (Apotex) Nd 0,04

Trimethoprim + sulfamethoxazole, 8/40 mg/ml / Liquid Apo-sulfatrim (Apotex) Nd 2,47

Trimethoprim + sulfamethoxazole, 8/40 mg/ml / Liquid Nu-Cotrimox (Nu-Pharm) Nd 2,47

Trimethoprim + sulfamethoxazole, 8/40 mg/ml / Liquid Septra (Glaxo Wellcome) Nd 2,60

Trimethoprim + sulfamethoxazole, 8/40 mg/ml / Liquid Novo-trimel (Novopharm) 0,011 0,011

Trimethoprim + sulfamethoxazole, 8/40 mg/ml / Liquid Bactrim Roche (Hoffman-La Roche) 1,81 2,42

Trimethoprim + sulfamethoxazole, 80/400 mg / Tablet Apo-sulfatrim (Apotex) Nd 0,15

Trimethoprim + sulfamethoxazole, 80/400 mg / Tablet Bactrim Roche (Hoffman-La Roche) Nd 0,20

Trimethoprim + sulfamethoxazole, 80/400 mg / Tablet Nu-Cotrimox (Nu-Pharm) Nd 0,15

Trimethoprim + sulfamethoxazole, 80/400 mg / Tablet Septra (Glaxo Wellcome) Nd 0,04

Trimethoprim + sulfamethoxazole, 80/400 mg / Tablet Novo-Trimel (Novopharm) 0,163 0,235

Trimethoprim, 100 mg / Tablet Proloprim (Glaxo Wellcome) 0,52 Nd

Trimethoprim, 200 mg / Tablet Proloprim (Glaxo Wellcome) 0,12 Nd

Trimipramine, maleate, 100 mg / Tablet Novo-Tripramine (Novopharm) 0,046 0,067

Trimipramine, maleate, 25 mg / Tablet Novo-Tripramine (Novopharm) 0,012 0,017

Trimipramine, maleate, 50 mg / Tablet Novo-Tripramine (Novopharm) 0,023 0,033

Trovafloxacin, 100 mg / Tablet Trovan (Pfizer) 0,388 Nd

Trovafloxacin, 200 mg / Tablet Trovan (Pfizer) 0,780 Nd

Valproic acid, 250 mg / Capsule Depakene (Abbott Laboratories) 0,00 Nd

Valproic acid, 250 mg / Capsule Pms-Valproic Acid (Pharmascience) 0,71 Nd

Valproic acid, 250 mg / Capsule Novo-Valproic (Novopharm) 0,90 Nd

Valproic acid, 50 mg/ml / Liquid Alti-Valproic (AltiMed Pharmaceutical Company) Nd 3,54

Valproic acid, 50 mg/ml / Liquid Pms-Valproic Acid (Pharmascience) 2,8 Nd

Valproic acid, 500 mg / Capsule Depakene (Abbot) 0,00 Nd

Valproic acid, 500 mg / Capsule Pms-Valproic Acid E.C. (Pharmascience) 0,00 Nd

Valproic acid, 500 mg / Capsule Pms-Valproic Acid (Pharmascience) 0,71 Nd

Valproic acid, 500 mg / Capsule Novo-Valproic (Novopharm) 0,88 Nd

Valproic acid, 50 mg/ml / Liquid Depakene (Abbott Laboratories) 2,97 3,54

Verapamil, 120 mg / Tablet Novo-Veramil (Novopharm) 0,083 0,096

Verapamil, 80 mg / Tablet Novo-Veramil (Novopharm) 0,055 0,064

Vigabatrin, 500 mg / Tablet Sabril (Hoechst Marion Roussel) 0,056 0,579

Vitamine a b c d, / Liquid Infantol drops (Carter Horner) Nd 2,8

Vitamine a b c d, / Liquid Infantol liquid (Carter Horner) Nd 1,16

Vitamine a b c d, / Liquid Polyvisol (Mead Johnson) 3,40 Nd

Vitamine a c d, / Liquid Tri-vi-sol (Mead Johnson) 2,20 Nd

Vitamine a c d + fluor, / Liquid Tri-vi-flor (Mead Johnson) 2,20 Nd

Vitamine a c d + fluor, / Liquid Tri-vi-sol with fluor (Mead Johnson) 2,20 Nd

Vitamine d, 400 u/ml / Liquid D-vi-sol 400 u/0.6 ml (Mead Johnson) 2,20 Nd

Vitamine e, 50 u/ml / Liquid Aquasol e (Novartis) 1,52 Nd

Vitamine e, 100 UI / Capsule Aquasol e (Novartis) 1,44 Nd

Vitamine e, 400 UI / Capsule Vitamine E (Santé NaturelleTM Adrien Gagnon) 0,29 Nd

Vitamines, multi-, / Capsule Fortamines-10 Capsule (Rougier) 0,36 Nd

Vitamines, multi-, / Tablet Fortamines-10 (Rougier) 0,36 Nd

Vitamines, multi-, / Tablet Maxi-10 (Rougier) 0,36 Nd

Zidovudine, 100 mg / Capsule Novo-AZT (Novopharm) 0,060 0,074

* The caloric content indicated is for one ml, one tablet or one capsule unless otherwise indicated. CH§ = carbohydrate.

Nd = No data. When no data is available for caloric content provided by carbohydrates, we suggest the use of total caloric content.

Volume 28, No. 4 – November 2001

THE CANADIAN JOURNALOF NEUROLOGICALSCIENCES

Table 2: Worst case scenario study data

Medication* Formulation Active Weight (g) Excipient Caloric Caloric Difference

ingredient (mg) weight (g) content, content (kCal) (kCal)

estimated (kCal)

Biaxin Tablet 250 0,5196 0,2696 1,0784 0,210 0,868

Cipro Tablet 250 0,3805 0,1305 0,522 0,171 0,351

Épival Tablet 250 0,4975 0,2475 0,99 0,170 0,820

Lamictal Tablet 25 0,0802 0,0552 0,2208 0,107 0,114

Novamoxin Capsule 250 0,3824 0,1324 0,5296 0,082 0,448

Novamoxin Capsule 500 0,7052 0,2052 0,8208 0,164 0,657

Novo-Carbamaz Tablet 200 0,2568 0,0568 0,2272 0,031 0,196

Novo-Chlorocap Capsule 250 0,5557 0,3057 1,2228 0,863 0,360

Novo-Chloroquine Tablet 250 0,7868 0,5368 2,1472 0,824 1,323

Novo-Chlorpromazine Tablet 100 0,3922 0,2922 1,1688 0,216 0,953

Novo-Cloxin Capsule 250 0,3884 0,1384 0,5536 0,139 0,415

Novo-Cloxin Capsule 500 0,6628 0,1628 0,6512 0,000 0,651

Novo-Dipiradol Tablet 50 0,1844 0,1344 0,5376 0,044 0,494

Novo-Doxepin Capsule 25 0,1987 0,1737 0,6948 0,428 0,267

Novo-Doxylin Capsule 100 0,3478 0,2478 0,9912 0,022 0,969

Novo-Furan Tablet 50 0,1784 0,1284 0,5136 0,073 0,441

Novo-Hydrazide Tablet 25 0,1047 0,0797 0,3188 0,238 0,081

Novo-Hydroxyzin Soft Gelatin 10 0,229 0,219 0,876 0,000 0,876

Novo-Hylazin Tablet 25 0,1522 0,1272 0,5088 0,182 0,327

Novo-Lexin Tablet 250 0,3622 0,1122 0,4488 0,075 0,374

Novo-Methacin Capsule 25 0,299 0,274 1,096 0,887 0,209

Novo-Naprox Tablet 250 0,3695 0,1195 0,478 0,075 0,403

Novo-Nidazol Tablet 250 0,5395 0,2895 1,158 0,585 0,573

Novo-Peridol Tablet 2 0,1258 0,1238 0,4952 0,025 0,470

Novo-Pheniram Tablet 4 0,2198 0,2158 0,8632 0,032 0,831

Novo-Pirocam Capsule 10 0,3959 0,3859 1,5436 1,056 0,488

Novo-Pranol Tablet 10 0,1345 0,1245 0,498 0,434 0,064

Novo-Prednisone Tablet 50 0,218 0,168 0,672 0,586 0,086

Novo-Purol Tablet 100 0,2989 0,1989 0,7956 0,458 0,338

Novo-Rythro estolate Capsule 250 0,5589 0,3089 1,2356 0,266 0,970

Novo-Semide Tablet 40 0,1648 0,1248 0,4992 0,360 0,139

Novo-Spiroton Tablet 25 0,262 0,237 0,948 0,895 0,053

Novo-Spiroton Tablet 100 0,6475 0,5475 2,19 2,042 0,148

Novo-Sucralate Tablet 1000 1,19 0,19 0,76 0,144 0,616

Novo-Tetra Capsule 250 0,3566 0,1066 0,4264 0,163 0,263

Novo-Trimel Tablet 480 0,5284 0,0484 0,1936 0,163 0,031

Novo-Triptyn Tablet 50 0,239 0,189 0,756 0,082 0,674

Novo-Veramil Tablet 80 0,2808 0,2008 0,8032 0,055 0,748

Novo-Zolamide Tablet 250 0,4977 0,2477 0,9908 0,100 0,891

Phenobarbital (Parke-Davis) Tablet 15 0,081 0,066 0,264 0,240 0,024

Phenobarbital (Parke-Davis) Tablet 30 0,1207 0,0907 0,3628 0,330 0,033

Pms-docusate sodium Capsule 100 0,4355 0,3355 1,342 0,510 0,832

Rifadin Soft Gelatin 300 0,4244 0,1244 0,4976 0,181 0,317

Sabril Tablet 500 0,6789 0,1789 0,7156 0,056 0,660

Stemetil Tablet 5 0,0822 0,0772 0,3088 0,000 0,309

Vitamine e (Adrien Gagnon) Capsule 294 0,5862 0,2922 1,1688 0,290 0,879

* Trade names.